FlyBase Allele Report: Dmel\NUCB1[c01508]

General Information

Symbol

Dmel\NUCB1^c01508

Species

D. melanogaster

Name

FlyBase ID

FBal0160149

Feature type

allele

Associated gene

Dmel\NUCB1

Associated Insertion(s)

PBac{PB}NUCB1^c01508

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{PB}NUCB1^c01508

Cytology

Description

Insertion of a PBac{PB} element immediately prior to the first predicted residue of the 7 amino acid Gα binding and activating (GBA) motif core. This introduces three in-frame stop codons, which is predicted to result in a truncated protein lacking the GBA motif and second EF-hand, as well as the variable repeat region.

(Balasubramanian and Srinivasan, 2020)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:17,798,877..17,798,877 [+]

(Ullastres et al., 2021, Balasubramanian and Srinivasan, 2020, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Itpr^ug3, Itpr^wc703

(Balasubramanian and Srinivasan, 2020)

modeled by Itpr^ug3, Itpr^wc361

(Balasubramanian and Srinivasan, 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Balasubramanian and Srinivasan, 2020, Bloomington Drosophila Stock Center, 2004.11.6)

viable

(Balasubramanian and Srinivasan, 2020, Bloomington Drosophila Stock Center, 2004.11.6)

Phenotype Manifest In

Detailed Description

Statement

Reference

NUCB1^c01508 hetero- and homozygotes do not show lethality, infertility, or any other obvious fitness-related, morphological/developmental, or behavioral abnormalities (as evidenced from assays for fecundity, lifespan, body weight, molting profile, wing posture, wing vein patterning, temperature-sensitive paralysis, flight or climbing ability, and multiple other phenotypic traits).

NUCB1^c01508 hetero- and homozygotes do not show significant changes in lifespan under a dead or live yeast diet, as compared to controls.

(Balasubramanian and Srinivasan, 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Itpr^wc703/Itpr^ug3, NUCB1^c01508, Orai^k11505 has abnormal flight phenotype, suppressible | partially by SERCA[+]/SERCA^Kum170

(Balasubramanian and Srinivasan, 2020)

Itpr^wc361/Itpr^ug3, NUCB1^c01508, Orai^k11505 has abnormal flight phenotype, suppressible | partially by SERCA[+]/SERCA^Kum170

(Balasubramanian and Srinivasan, 2020)

Suppressor of

Statement

Reference

NUCB1^c01508/NUCB1[+] is a suppressor | partially of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1^c01508 is a suppressor | partially of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, NUCB1^trunc.UAS, NUCB1[+], Scer\GAL4^NP3084 is a suppressor | partially of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a suppressor of visible | adult stage phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^c01508, SERCA^Kum170, NUCB1[+] is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+]/SERCA^Kum170, NUCB1^c01508/NUCB1^c01508 is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Orai[+], Orai^k11505, NUCB1[+] is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1^c01508 is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+]/Orai^k11505, NUCB1^c01508/NUCB1^c01508 is a suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Orai[+], Orai^k11505, NUCB1[+] is a suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a suppressor of visible | adult stage phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a suppressor of increased mortality during development phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+]/SERCA^Kum170, NUCB1^c01508/NUCB1^c01508 is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^c01508, SERCA^Kum170, NUCB1[+] is a suppressor of increased mortality during development | cold sensitive phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+]/Orai^k11505, NUCB1^c01508/NUCB1^c01508 is a suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Orai[+], Orai^k11505, NUCB1[+] is a suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Itpr^90B.0, NUCB1[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Itpr^ug3, NUCB1[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

NOT Suppressor of

Statement

Reference

NUCB1^c01508/NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3, Orai[+]/Orai^k11505, SERCA[+]/SERCA^Kum170

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3, Orai^k11505, SERCA^Kum170

(Balasubramanian and Srinivasan, 2020)

SERCA[+]/SERCA^Kum170, NUCB1^c01508/NUCB1^c01508 is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^c01508, SERCA^Kum170, NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, Itpr^ug3, NUCB1[+] is a non-suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508, SPoCk^{A.UAS.Tag:MYC}, NUCB1[+], Scer\GAL4^NP3084 is a non-suppressor of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^UAS.FL, NUCB1^c01508, NUCB1[+], Scer\GAL4^NP3084 is a non-suppressor of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1^c01508 is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+]/SERCA^Kum170, NUCB1^c01508/NUCB1^c01508 is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^c01508, SERCA^Kum170, NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1^c01508 is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Other

Statement

Reference

Itpr^wc361/Itpr^ug3, NUCB1^c01508, Orai^k11505 has abnormal flight phenotype

(Balasubramanian and Srinivasan, 2020)

Itpr^wc703/Itpr^ug3, NUCB1^c01508, Orai^k11505 has abnormal flight phenotype

(Balasubramanian and Srinivasan, 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

NUCB1^c01508/NUCB1[+] is a suppressor of wing phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^c01508/NUCB1[+] is a suppressor of wing phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10581

w¹¹¹⁸; PBac{PB}NUCB1^c01508

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

NUCB1^c01508

dmnucb1^c01508

(Balasubramanian and Srinivasan, 2020)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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