FlyBase Allele Report: Dmel\nAChRα6[EY13897]

General Information

Symbol

Dmel\nAChRα6^EY13897

Species

D. melanogaster

Name

FlyBase ID

FBal0158905

Feature type

allele

Associated gene

Dmel\nAChRα6

Associated Insertion(s)

P{EPgy2}nAChRα6^EY13897

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}nAChRα6^EY13897

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,835,996..9,835,996 [-]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Gene Disruption Project members, 2001-)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

indirect flight muscle cell

(Kucherenko et al., 2011)

indirect flight muscle cell (with nAChRα6^KG05852)

(Kucherenko et al., 2011)

Detailed Description

Statement

Reference

nAChRα6^EY13897 mutant flies show significant indirect flight muscle degeneration compared to controls.

nAChRα6^EY13897/nAChRα6^KG05852 mutant flies show significant indirect flight muscle degeneration compared to controls.

(Kucherenko et al., 2011)

nAChRα6^EY13897 mutant third instar larvae do not show any significant defects in axon migration in the brain compared to controls.

(Marrone et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

nAChRα6^EY13897/nAChRalpha6[+] is an enhancer of visible phenotype of Dg^RNAi.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

Suppressor of

Statement

Reference

nAChRα6^EY13897/nAChRalpha6[+] is a suppressor of visible phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

nAChRα6^EY13897/nAChRalpha6[+] is a suppressor of visible phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

Other

Statement

Reference

Dys^E6, nAChRα6^EY13897/nAChRalpha6[+] has visible phenotype

(Kucherenko et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

nAChRα6^EY13897/nAChRalpha6[+] is an enhancer of posterior crossvein phenotype of Dg^RNAi.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

NOT Enhancer of

Statement

Reference

nAChRα6^EY13897/nAChRalpha6[+] is a non-enhancer of indirect flight muscle cell phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2011)

nAChRα6^EY13897/nAChRalpha6[+] is a non-enhancer of indirect flight muscle cell phenotype of Dg^RNAi.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2011)

Suppressor of

Statement

Reference

nAChRα6^EY13897/nAChRalpha6[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.NH2.UAS, Scer\GAL4^Act.PU

(Kucherenko et al., 2008)

nAChRα6^EY13897/nAChRalpha6[+] is a suppressor of posterior crossvein phenotype of Dys^RNAi.C.UAS, Scer\GAL4^Tub.PU

(Kucherenko et al., 2008)

Other

Statement

Reference

Df(3R)Exel6184/+, nAChRα6^EY13897 has indirect flight muscle cell phenotype

(Kucherenko et al., 2011)

Dys^E6, nAChRα6^EY13897/nAChRalpha6[+] has posterior crossvein phenotype

(Kucherenko et al., 2008)

Dys^RNAi.NH2.UAS, nAChRα6^EY13897/nAChRalpha6[+] has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

Dys^RNAi.C.UAS, nAChRα6^EY13897/nAChRalpha6[+] has wing vein | ectopic phenotype

(Kucherenko et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

nAChRα6 Dys double heterozygous flies (nAChRα6^EY13897/Df(3R)Exel6184) exhibit indirect flight muscle degeneration.

nAChRα6^EY13897 Dg^O86 double heterozygous flies do not exhibit indirect flight muscle degeneration.

One copy of nAChRα6^EY13897 does not enhance the indirect flight muscle degeneration seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU.

One copy of nAChRα6^EY13897 does not enhance the indirect flight muscle degeneration seen when Dg^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU.

nAChRα6^EY13897 Dg³²³ double heterozygous flies do not exhibit indirect flight muscle degeneration.

(Kucherenko et al., 2011)

One copy of nAChRα6^EY13897 weakly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.NH2.Scer\UAS} is expressed under the control of Scer\GAL4^Act.PU but produces extra wing vein material.

One copy of nAChRα6^EY13897 weakly suppresses the detached posterior crossvein phenotype seen when Dys^{dsRNA.C.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU but produces extra wing vein material.

One copy of nAChRα6^EY13897 in a Dys^E6/+ background results in posterior crossvein defects.

One copy of nAChRα6^EY13897 enhances the posterior crossvein phenotype seen when Dg^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^tub.PU.

(Kucherenko et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20783

y¹ w^67c23; P{EPgy2}nAChRα6^EY13897

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

nAChRalpha^EY13897

(Kucherenko et al., 2011)

nAChRΑ-30D^EY13897

(Kucherenko et al., 2008)

nAChRα6^EY13897

nAcRα-30D^EY13897

(Marrone et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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