FB2024_03 , released June 25, 2024
Allele: Dmel\nAChRα6KG05852
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General Information
Symbol
Dmel\nAChRα6KG05852
Species
D. melanogaster
Name
FlyBase ID
FBal0137139
Feature type
allele
Associated gene
Dmel\nAChRα6
Associated Insertion(s)
P{SUPor-P}nAChRα6KG05852
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}nAChRα6KG05852
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nAChRα6EY13897/nAChRα6KG05852 mutant flies show significant indirect flight muscle degeneration compared to controls.

      (Kucherenko et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      nAChRα6KG05852 is an enhancer of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      nAChRα6KG05852/nAChRalpha6[+] is a non-enhancer of indirect flight muscle cell phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)

      nAChRα6KG05852/nAChRalpha6[+] is a non-enhancer of indirect flight muscle cell phenotype of DgRNAi.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      nAChRα6 Dys double heterozygous flies (nAChRα6KG05852/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration.

      nAChRα6KG05852 DgO86 double heterozygous flies do not exhibit indirect flight muscle degeneration.

      One copy of nAChRα6KG05852 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      One copy of nAChRα6KG05852 does not enhance the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

      nAChRα6KG05852 Dg323 double heterozygous flies do not exhibit indirect flight muscle degeneration.

      (Kucherenko et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      nAChRalphaKG05852
      (Kucherenko et al., 2011)
      nAChRα6KG05852
      nAcRα-30DKG05852
      (Walker et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)