FlyBase Allele Report: Dmel\wgn[e00637]

General Information

Symbol

Dmel\wgn^e00637

Species

D. melanogaster

Name

FlyBase ID

FBal0158488

Feature type

allele

Associated gene

Dmel\wgn

Associated Insertion(s)

PBac{RB}wgn^e00637

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{RB}wgn^e00637

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:18,632,455..18,632,455 [-]

(Ruan et al., 2013, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Ruan et al., 2013)

fertile

(Bloomington Drosophila Stock Center, 2004.11.6)

viable

(Bloomington Drosophila Stock Center, 2004.11.6)

Phenotype Manifest In

lamina plexus | third instar larval stage

(Ruan et al., 2013)

medulla | third instar larval stage

(Ruan et al., 2013)

Detailed Description

Statement

Reference

The normal smooth structure of the laminar plexus is replaced by large aggregates separated by gaps in hemizygous third instar larvae. Abnormally thick axons bundles are seen in the medulla, and medullar axons often stray into neighbouring regions. The growth cones in the medulla are enlarged and often overlap with each other. This phenotype is 70% penetrant.

(Ruan et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

wgn^e00637 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Moe^G0323/Moe[+]

(Ruan et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

wgn^e00637 has lamina plexus | third instar larval stage phenotype, enhanceable by Moe^G0323/Moe[+]

(Ruan et al., 2013)

wgn^e00637 has medulla | third instar larval stage phenotype, enhanceable by Moe^G0323/Moe[+]

(Ruan et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Moe^G0323/+ increases the penetrance of the axonal mistargeting defects seen in the lamina and medulla of hemizygous wgn^e00637 third instar larvae from 70% to 100%.

(Ruan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17874

w¹¹¹⁸ PBac{RB}wgn^e00637

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

wgn^e00637

(Ruan et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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