FlyBase Allele Report: Dmel\brwl[KG00824]

General Information

Symbol

Dmel\brwl^KG00824

Species

D. melanogaster

Name

FlyBase ID

FBal0156983

Feature type

allele

Associated gene

Dmel\brwl

Associated Insertion(s)

P{SUPor-P}brwl^KG00824

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}brwl^KG00824

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,568,920..9,568,920 [+]

(FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis (with brwl^MI05456)

(Shukla et al., 2018)

decreased occurrence of cell division | oogenesis (with brwl^MI05456)

(Shukla et al., 2018)

increased cell death | oogenesis (with brwl^MI05456)

(Shukla et al., 2018)

viable | recessive

(Shukla et al., 2018)

Phenotype Manifest In

egg chamber (with brwl^MI05456)

(Shukla et al., 2018)

female germline cell (with brwl^MI05456)

(Shukla et al., 2018)

fusome (with brwl^MI05456)

(Shukla et al., 2018)

oocyte (with brwl^MI05456)

(Shukla et al., 2018)

ovary (with brwl^MI05456)

(Shukla et al., 2018)

ring canal (with brwl^MI05456)

(Shukla et al., 2018)

spectrosome (with brwl^MI05456)

(Shukla et al., 2018)

synaptonemal complex (with brwl^MI05456)

(Shukla et al., 2018)

Detailed Description

Statement

Reference

brwl^KG00824 is homozygous viable; heterozygotes only rarely show ovary defects.

brwl^KG00824/brwl^MI05456 transheterozygotes show an array of highly prevalent and progressive ovary defects, including ovariole architecture defects, egg chambers showing decreased cell division, apoptosis, loss of ring canals, mispositioned or absent oocyte, fused egg chambers and degenerated egg chambers, as compared to controls; the germaria show progressive decreases in the number of germline cells, in synaptonemal complex formation, and in the numbers of spectrosome-positive and fusome-positive cysts, as compared to controls.

(Shukla et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

brwl^KG00824/brwl^MI05456 has decreased cell number | oogenesis phenotype, suppressible | partially by stwl^{UAS.Tag:HA,Tag:FLAG}/Scer\GAL4^{VP16.nanos.UTR}

(Shukla et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

brwl^KG00824/brwl^MI05456 has ovary phenotype, suppressible | partially by stwl^{UAS.Tag:HA,Tag:FLAG}/Scer\GAL4^{VP16.nanos.UTR}

(Shukla et al., 2018)

brwl^KG00824/brwl^MI05456 has egg chamber phenotype, suppressible | partially by stwl^{UAS.Tag:HA,Tag:FLAG}/Scer\GAL4^{VP16.nanos.UTR}

(Shukla et al., 2018)

brwl^KG00824/brwl^MI05456 has oocyte phenotype, suppressible | partially by stwl^{UAS.Tag:HA,Tag:FLAG}/Scer\GAL4^{VP16.nanos.UTR}

(Shukla et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The progressive oogenesis defects observed in brwl^KG00824/brwl^MI05456 transheterozygotes (fused egg chambers, apoptotic egg chambers, absent occyte) are delayed by the expression of stwl^{UAS.Tag:HA,Tag:FLAG} under the control of Scer\GAL4^VP16.nos.UTR.

(Shukla et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12901

y¹ w^67c23; P{SUPor-P}brwl^KG00824

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG3838^KG00824

brwl^KG00824

(Shukla et al., 2018)

brwl^KG0

(Shukla et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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