FlyBase Allele Report: Dmel\sotv[326]

General Information

Symbol

Dmel\sotv³²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0156461

Feature type

allele

Associated gene

Dmel\sotv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Takei et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: E626term.

(Takei et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:16,146,660..16,146,660 [-]

Nucleotide change:

G16146660T

Amino acid change:

E626term | sotv-PB

Reported amino acid change:

E626term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Takei et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage (with Df(2R)Jp8)

(Takei et al., 2004)

some die during pupal stage (with Df(2R)Jp8)

(Takei et al., 2004)

Phenotype Manifest In

eye | P-stage (with Df(2R)Jp8)

(Takei et al., 2004)

imaginal disc | larval stage (with Df(2R)Jp8)

(Takei et al., 2004)

leg | P-stage (with Df(2R)Jp8)

(Takei et al., 2004)

wing | somatic clone

(Takei et al., 2004)

wing disc | larval stage (with Df(2R)Jp8)

(Takei et al., 2004)

Detailed Description

Statement

Reference

Ext2³²⁶/Df(2R)Jp8 animals die as pupae with small eyes and legs. Third instar larvae have smaller discs than the wild type, and in particular, their wing discs are narrower in an anterior-posterior direction. Some tissue is deleted within somatic clones of Ext2³²⁶ homozygous cells in the adult wing.

(Takei et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Ext2[+]/sotv³²⁶ is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Ext2[+], sotv³²⁶, ttv[+], ttv^00681b is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

NOT Suppressor of

Statement

Reference

Ext2[+]/sotv³²⁶ is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Ext2[+], sotv³²⁶, ttv[+], ttv^00681b is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Ext2[+]/sotv³²⁶ is a non-enhancer of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Ext2[+], sotv³²⁶, ttv[+], ttv^00681b is a non-enhancer of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

NOT Suppressor of

Statement

Reference

Ext2[+]/sotv³²⁶ is a non-suppressor of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Ext2[+], sotv³²⁶, ttv[+], ttv^00681b is a non-suppressor of larval posterior commissure | embryonic stage phenotype of Scer\GAL4^P52, Sema1a^UAS.cYa, Sema1a^k13702

(Cho et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The commissural axon phenotype (failure to cross the midline) seen in embryos expressing Sema-1a^Scer\UAS.cYa under the control of Scer\GAL4^P52 in a Sema-1a^k13702 null background is not affected if the embryos are also heterozygous for Ext2³²⁶.

(Cho et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

sotv³²⁶/Df(2R)Jp8 is rescued by sotv^αTub84B.PT

(Takei et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ext2³²⁶

sotv³²⁶

(Sekine et al., 2013, Cho et al., 2012, Takei et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (3)

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