FlyBase Allele Report: Dmel\Sdc[unspecified]

General Information

Symbol

Dmel\Sdc^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0155817

Feature type

allele

Associated gene

Dmel\Sdc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sdc^unspecified has abnormal neuroanatomy phenotype, enhanceable by lea[+]/robo2^lea-1

(Steigemann et al., 2004)

Sdc^unspecified has abnormal neuroanatomy phenotype, enhanceable by robo[+]/robo1^Q1-15

(Steigemann et al., 2004)

Sdc^unspecified has abnormal neuroanatomy phenotype, enhanceable by sli²/sli[+]

(Steigemann et al., 2004)

Sdc^unspecified has abnormal neuroanatomy phenotype, enhanceable by robo2^lea-1/robo2^lea-1

(Steigemann et al., 2004)

Enhancer of

Statement

Reference

Sdc^unspecified/Sdc^unspecified is an enhancer of abnormal neuroanatomy phenotype of robo2^lea-1

(Steigemann et al., 2004)

NOT Enhancer of

Statement

Reference

Sdc^unspecified is a non-enhancer of abnormal neuroanatomy phenotype of robo1^Q1-15

(Steigemann et al., 2004)

Other

Statement

Reference

Sdc[+]/Sdc^unspecified, sli² has abnormal neuroanatomy phenotype

(Steigemann et al., 2004)

Sdc^unspecified, sli² has abnormal neuroanatomy phenotype

(Steigemann et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sdc^unspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by lea[+]/robo2^lea-1

(Steigemann et al., 2004)

Sdc^unspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by robo[+]/robo1^Q1-15

(Steigemann et al., 2004)

Sdc^unspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by sli²/sli[+]

(Steigemann et al., 2004)

Sdc^unspecified has presumptive embryonic/larval central nervous system phenotype, enhanceable by robo2^lea-1/robo2^lea-1

(Steigemann et al., 2004)

Sdc^unspecified has embryonic somatic muscle cell | ventral phenotype, enhanceable by robo2^lea-1/robo2^lea-1

(Steigemann et al., 2004)

Enhancer of

Statement

Reference

Sdc[+]/Sdc^unspecified is an enhancer of presumptive embryonic/larval central nervous system phenotype of sli²

(Steigemann et al., 2004)

Sdc^unspecified/Sdc^unspecified is an enhancer of presumptive embryonic/larval central nervous system phenotype of robo2^lea-1

(Steigemann et al., 2004)

Sdc^unspecified/Sdc^unspecified is an enhancer of embryonic somatic muscle cell | ventral phenotype of robo2^lea-1

(Steigemann et al., 2004)

NOT Enhancer of

Statement

Reference

Sdc^unspecified is a non-enhancer of presumptive embryonic/larval central nervous system phenotype of robo1^Q1-15

(Steigemann et al., 2004)

Sdc^unspecified is a non-enhancer of embryonic somatic muscle cell | ventral phenotype of robo1^Q1-15

(Steigemann et al., 2004)

Other

Statement

Reference

Sdc[+]/Sdc^unspecified, sli² has A1-7 lateral transverse muscle cell | increased number phenotype

(Steigemann et al., 2004)

Sdc^unspecified, sli² has A1-7 lateral transverse muscle cell | increased number phenotype

(Steigemann et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The number of ventral muscles that cross the midline in lea¹ Sdc^unspecified double mutant embryos is significantly increased compared to either single mutant. The longitudinal axons collapse along the ventral midline and form a single fascicle. robo^Q1-15 Sdc^unspecified embryos do not show enhancement of the muscle and central nervous system midline crossing phenotypes seen in robo^Q1-15 embryos. sli² Sdc^unspecified double heterozygous embryos have additional longitudinal transverse muscles. The number of Fas2-expressing inner fascicles that cross the midline in the double heterozygotes (3.3%) is increased compared to sli² single heterozygotes (0.6%). Sdc^unspecified homozygous embryos that are also heterozygous for one of robo^Q1-15, lea¹ or sli² show an enhanced axonal guidance defect with multiple midline crossings of the fascicles.

(Steigemann et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sdc^unspecified is rescued by Scer\GAL4^elav-C155/Sdc^UAS.cSa

(Steigemann et al., 2004)

Not rescued by

Sdc^unspecified is not rescued by Sdc^UAS.cSa/Scer\GAL4^sim.PS

(Steigemann et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sdc^unspecified

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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