FB2024_03 , released June 25, 2024
Allele: Dmel\robo2lea-1
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General Information
Symbol
Dmel\robo2lea-1
Species
D. melanogaster
Name
FlyBase ID
FBal0011612
Feature type
allele
Associated gene
Dmel\robo2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos show a low frequency of muscles crossing the ventral midline. 36% of inner Fas2-positive axons cross the ventral midline at stages 16 and 17.

      (Steigemann et al., 2004)

      Embryos have a mutant central nervous system phenotype. lea1/leaS4-14 embryos have a defective head skeleton and the H-piece does not form. The dorsal bridge still forms.

      (Schimmelpfeng et al., 2001)

      Head involution is incomplete. Abdominal transformations occur in combination with Pc-like mutants.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Statement
      Reference

      lea[+]/robo2lea-1 is an enhancer of abnormal neuroanatomy phenotype of Sdcunspecified

      (Steigemann et al., 2004)

      robo2lea-1/robo2lea-1 is an enhancer of abnormal neuroanatomy phenotype of Sdcunspecified

      (Steigemann et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The number of ventral muscles that cross the midline in lea1 Sdcunspecified double mutant embryos is significantly increased compared to either single mutant. The longitudinal axons collapse along the ventral midline and form a single fascicle. Sdcunspecified homozygous embryos that are also heterozygous for lea1 show an enhanced axonal guidance defect with multiple midline crossings of the fascicles.

      (Steigemann et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      lea1
      lea25
      (Tearle and Nusslein-Volhard, 1987)
      leak1
      (Steigemann et al., 2004)
      robo2lea-1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)