FB2024_03 , released June 25, 2024
Allele: Dmel\chifEY05746
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General Information
Symbol
Dmel\chifEY05746
Species
D. melanogaster
Name
FlyBase ID
FBal0155502
Feature type
allele
Associated gene
Dmel\chif
Associated Insertion(s)
P{EPgy2}chifEY05746
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}chifEY05746
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  muscular dystrophy
      modeled by DgO86
      (Kucherenko et al., 2011)
      modeled by DgRNAi.UAS
      (Kucherenko et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

      (Kucherenko et al., 2011)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      chifEY05746/chifA507 mutant flies show significant indirect flight muscle degeneration compared to controls.

      chifEY05746/chifBG02820a mutant flies show significant indirect flight muscle degeneration compared to controls.

      (Kucherenko et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      chif Dys double heterozygous flies (chifEY05746/Df(3R)Exel6184) exhibit indirect flight muscle degeneration.

      chifEY05746 DgO86 double heterozygous flies exhibit indirect flight muscle degeneration.

      One copy of chifEY05746 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      One copy of chifEY05746 enhances the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

      chifEY05746 Dg323 double heterozygous flies do not exhibit indirect flight muscle degeneration.

      (Kucherenko et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      chifEY05746
      (Kucherenko et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)