FlyBase Allele Report: Dmel\Nrg[G0488b]

General Information

Symbol

Dmel\Nrg^G0488b

Species

D. melanogaster

Name

FlyBase ID

FBal0152358

Feature type

allele

Associated gene

Dmel\Nrg

Associated Insertion(s)

P{lacW}Nrg^G0488b

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Peter et al., 2002, Schäfer et al., 1999.12.2)

Progenitor genotype

Associated Insertion(s)

P{lacW}Nrg^G0488b

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,531,344..8,531,533 [+]

(Peter et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426789

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | female (with Nrg⁸⁴⁹)

(Carhan et al., 2005)

abnormal courtship behavior | female (with Nrg⁸⁹²)

(Carhan et al., 2005)

lethal (with Nrg^l10)

(Carhan et al., 2005)

lethal | recessive

(Schäfer et al., 1999.12.2)

lethal - all die during embryonic stage

(Peter et al., 2002)

some die during embryonic stage

(Peter et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Nrg^G0488b/Nrg^l10 females are inviable at both 18 and 25[o]C.

Nrg^G0488b/Nrg⁸⁴⁹ and Nrg^G0488b/Nrg⁸⁹² females show reduced sexual receptivity compared to controls when mated to wild-type males.

(Carhan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Nrg^ibx

(Carhan et al., 2005)

Nrg^l10

(Carhan et al., 2005)

Comments

Nrg^G0488b fails to complement the reduced female receptivity phenotype of Nrg^ibx and of Nrg⁸⁹².

(Carhan et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

111935

w^67c23 P{lacW}Nrg^G0488b P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Stated in FBrf0125103 that the P{lacW}Nrg^G0488b insertion was isolated from a multiple insertion line, with a second site at 3A (identified by in situ hybridization). Retracted in FBrf0173192; site at 3A stated to have been artifactual.

(Schäfer, 2004.1.8)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426789

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Nrg^G0488b

l(1)G0488

(Peter et al., 2002)

l(1)G0488^G0488

(Schäfer et al., 1999.12.2)

l(1)G0488b

(Carhan et al., 2005)

Name Synonyms

Secondary FlyBase IDs

FBal0103713

References (4)

Report Sections

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