FB2024_03 , released June 25, 2024
Allele: Dmel\Mmp2A218V
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General Information
Symbol
Dmel\Mmp2A218V
Species
D. melanogaster
Name
FlyBase ID
FBal0150752
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Page-McCaw et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: A218V.

(Page-McCaw et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,614,916..9,614,916 [-]
Nucleotide change:

C9614916T

Amino acid change:

A218V | Mmp2-PB; A66V | Mmp2-PC; A110V | Mmp2-PD

Reported amino acid change:

A218V

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Page-McCaw et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mmp2A218V mutant animals survive to 3rd instar, and 94% pupariate, but only 25% undergo head eversion, 8% develop head bristles and none eclose. Mutant late pupae/pharate adults often have a cleft bisecting the notum along the midline. Mmp2A218V/Mmp2Df animals survive to third instar, and 96% pupariate, but only 13% undergo head eversion, 6% develop head bristles and none eclose.

      (Page-McCaw et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Other
      Statement
      Reference

      Mmp1Q273stop, Mmp2A218V has fat body phenotype

      (Jia et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A moderate delay in fat body cell dissociation during metamorphosis is seen in Mmp1Q273stop Mmp2A218V double heterozygotes.

      (Jia et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmp2A218V
      (Yang et al., 2019, Jia et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)