FB2024_03 , released June 25, 2024
Allele: Dmel\Mmp2Df
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General Information
Symbol
Dmel\Mmp2Df
Species
D. melanogaster
Name
FlyBase ID
FBal0150751
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Page-McCaw et al., 2003)
Progenitor genotype
Caused by aberration
Df(2R)Uba1-Mmp2
Cytology
Description

Removes part of the upstream gene Uba1, all the Mmp2 5' and promoter sequence, the first three Mmp2 exons encoding the signal sequence, the pro-domain, and some of the catalytic domain.

(Page-McCaw et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      94% of Mmp2G535R/Mmp2Df animals survive to third instar, all of which pupariate, 47% undergo head eversion, 18% develop head bristles, but none eclose. 74% (n = 23) of these pupae have a melanized lump in the developing thorax, visible as a black spot through the pupal case. The black spot appears before head eversion, varies in size, and remains evident in animals with fully developed legs and bristles. Mmp2A218V/Mmp2Df animals survive to third instar, and 96% pupariate, but only 13% undergo head eversion, 6% develop head bristles and none eclose.

      (Page-McCaw et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmp2Df
      Name Synonyms
      Secondary FlyBase IDs
        References (1)