FlyBase Allele Report: Dmel\Eip75B[A81]

General Information

Symbol

Dmel\Eip75B^A81

Species

D. melanogaster

Name

FlyBase ID

FBal0147921

Feature type

allele

Associated gene

Dmel\Eip75B

Associated Insertion(s)

Carried in Construct

Also Known As

E75^A81

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bialecki et al., 2002)

Progenitor genotype

Eip75B⁰⁰²²⁵

(Bialecki et al., 2002)

Cytology

Description

Imprecise excision of P{PZ}Eip75B⁰³³³⁸ has caused a deletion removing approximately 1792 bp, that extends from approx. 1.3 kb upstream of the Eip75B A-isoform transcription start site (in the Eip75B second intron) to 143 bp downstream from the start codon.

(Bialecki et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with Eip75B^Δ51)

(Bialecki et al., 2002)

lethal | pharate adult stage (with Eip75B^Δ51)

(Bialecki et al., 2002)

lethal - all die before end of second instar larval stage (with Eip75B^Δ51)

(Chen et al., 2008)

partially lethal - majority die | larval stage (with Eip75B^Δ51)

(Bialecki et al., 2002)

partially lethal - majority die | prepupal stage (with Eip75B^Δ51)

(Bialecki et al., 2002)

Phenotype Manifest In

embryonic/larval anterior spiracle (with Eip75B^Δ51)

(Bialecki et al., 2002)

mouth hook (with Eip75B^Δ51)

(Bialecki et al., 2002)

Detailed Description

Statement

Reference

Eip75B^A81/Eip75B^A81 mutant mushroom body neuron clones do not display any defects in regrowth innervation of the adult gamma lobe, as compared to wild type.

(Rabinovich et al., 2016)

Almost all Eip75B^A81/Eip75B^Δ51 mutant second instar larvae fail to molt and develop to later stages. Feeding ecdysone to these second instar larvae rescues 50% of them to the pupal stage.

(Chen et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

23654

Eip75B^A81/TM6B, P{Ubi-GFP.S65T}PAD2, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E75^A81

(Rabinovich et al., 2016, Chen et al., 2008, Bialecki et al., 2002)

E75A81

(Chen et al., 2008)

Eip75B^A81

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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