FB2024_03 , released June 25, 2024
Allele: Dmel\painEP2462
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General Information
Symbol
Dmel\painEP2462
Species
D. melanogaster
Name
FlyBase ID
FBal0146950
Feature type
allele
Associated gene
Dmel\pain
Associated Insertion(s)
P{EP}painEP2462
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Tracey et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{EP}painEP2462
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      painGAL4/painEP2462 trans-heterozygous flies exhibit strong male-male courtship behavior.

      (Wang et al., 2011)

      Mutant larvae do not show the cardiac pauses during motion which are seen in wild-type larvae.

      Basal cardiac activity (measured in anaesthetised animals) is increased in heterozygous larvae compared to wild-type controls.

      Contractility of the heart tube is reduced in heterozygous larvae compared to wild-type controls.

      Semi-dissected heart tubes in which local pressure is applied to segment A6 do not show cardiac arrest after the pressure is applied, in contrast to wild-type heart tubes, which under these conditions undergo cardiac arrest of an average duration of 25.8 +/- 1.6 seconds.

      The cardiac rhythm of semi-dissected heart tubes is not modified by hypo-osmotic shock (in contrast to wild-type).

      (Sénatore et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      painEP2451

      (Tracey et al., 2003)

      painEP2621

      (Tracey et al., 2003)

      painEP2251

      (Tracey et al., 2003)
      Rescued by

      painEP2462 is rescued by painUAS.cSa/Scer\GAL4unspecified

      (Sénatore et al., 2010)

      painEP2462 is rescued by painUAS.cSa/Scer\GAL4NP1029

      (Sénatore et al., 2010)
      Comments

      Expression of painScer\UAS.cSa in the heart under the control of Scer\GAL4unspecified rescues cardiac pauses during motion in painEP2462 mutant larvae.

      Expression of painScer\UAS.cSa under the control of Scer\GAL4NP1029 restores basal cardiac activity to wild-type levels in painEP2462 mutant larvae.

      (Sénatore et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      pain4
      (Sénatore et al., 2010)
      pain4
      (Tracey et al., 2003)
      painEP2462
      Name Synonyms
      painless4
      (Wang et al., 2011)
      Secondary FlyBase IDs
        References (3)