FlyBase Allele Report: Dmel\hrg[PAP21]

General Information

Symbol

Dmel\hrg^PAP21

Species

D. melanogaster

Name

FlyBase ID

FBal0144243

Feature type

allele

Associated gene

Dmel\hrg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Juge et al., 2002)

Progenitor genotype

hrg^k07618

(Juge et al., 2002)

Cytology

Description

Imprecise excision of the P{lacW} insertion from hrg^k07618 deletes the first 44 residues of hrg. Most of the 5'-UTR of the longest mRNAs as well as the embryonic transcription start site has also been removed.

(Juge et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates oculopharyngeal muscular dystrophy

modeled by Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | germline clone

(Juge et al., 2002)

lethal

(Juge et al., 2002)

Phenotype Manifest In

dorsal bridge

(Juge et al., 2002)

Detailed Description

Statement

Reference

Mutants are lethal from late embryonic to second instar larval stages. A slight defect in the head skeleton is seen - the dorsal bridge is distorted.

(Juge et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hrg^PAP21/hrg[+] is an enhancer of visible phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

hrg^PAP21/hrg[+] is an enhancer of lethal | embryonic stage | maternal effect phenotype of orb^mel

(Benoit et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

hrg^PAP21/hrg[+] is an enhancer of wing phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

hrg^PAP21 is an enhancer of ovary phenotype of orb^mel

(Juge et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The percentage of maternal effect embryonic lethality seen in embryos derived from orb^mel homozygous females is increased by heterozygosity for hrg^PAP21. The percentage of ventralised embryos is increased by heterozygosity for one copy of hrg^PAP21.

Oogenesis is blocked at stage 8 in 34% of hrg^PAP21/+ ; orb^mel females.

(Benoit et al., 2008)

hrg^PAP21/+; orb^mel lay almost no eggs. In these females oogenesis stops most frequently at stage 7/8 after which egg chambers degenerate, even though one or two stage 14 oocytes per ovary can be observed.

(Juge et al., 2002)

Xenogenetic Interactions

Statement

Reference

hrg^PAP21 enhances the wing posture defects seen upon expression of Hsap\PABPN1^17ala.Act88F.

(Chartier et al., 2015)

Complementation and Rescue Data

Partially rescued by

hrg^PAP21 is partially rescued by hrg^+7.9

(Juge et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotypic analysis suggests the following allelic series: hrg^PAP12 > hrg^PAP21 > hrg^PAP45.

(Juge et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hrg^PAP21

(Chartier et al., 2015, Benoit et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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