FlyBase Allele Report: Dmel\wdb[IP]

General Information

Symbol

Dmel\wdb^IP

Species

D. melanogaster

Name

FlyBase ID

FBal0143111

Feature type

allele

Associated gene

Dmel\wdb

Associated Insertion(s)

P{EP}EP3559

Carried in Construct

Also Known As

wdb^EP3559

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hannus et al., 2002)

P-element activity

(Hannus et al., 2002)

Progenitor genotype

P{EP}EP3559

(Hannus et al., 2002)

Associated Insertion(s)

P{EP}EP3559

Cytology

Description

In addition, the P{EP}wdb^EP3559 insertion is still present on the chromosome.

(Hannus et al., 2002)

Amino acid replacement: Q332term.

(Hannus et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:27,566,275..27,566,275 [-]

Nucleotide change:

C27566275T

Amino acid change:

Reported amino acid change:

Q332term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The P{EP}wdb^EP3559 insertion is also present on the chromosome.

(Hannus et al., 2002)

transposable_element_insertion_site

3R:27,582,191..27,582,191 [-]

(Hannus et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with wdb^dw)

(Hannus et al., 2002)

increased cell death | larval stage | somatic clone

(Vereshchagina et al., 2008)

lethal | recessive

(Hannus et al., 2002)

visible | somatic clone

(Vereshchagina et al., 2008, Hannus et al., 2002)

Phenotype Manifest In

eye | somatic clone

(Vereshchagina et al., 2008, Hannus et al., 2002)

eye disc | somatic clone

(Vereshchagina et al., 2008)

wing | somatic clone

(Hannus et al., 2002)

wing hair (with wdb^dw)

(Hannus et al., 2002)

Detailed Description

Statement

Reference

Homozygous clones do not generate any defects in the self-renewal of larval brain neuroblasts.

(Wang et al., 2009)

wdb^IP mutant eyes show no normal eye tissue, and differentiated adult ommatidia do not form.

In large wdb^IP mutant clones, cells are frequently extruded basally from mutant eye imaginal discs. Elevated levels of cell death are observed throughout eye discs.

(Vereshchagina et al., 2008)

Overexpression of wdb^IP under the control of Scer\GAL4^ap-md544 (using the P{EP}wdb^EP3559 insertion) results in no cells in the fifth wing cell having a multiple wing hair phenotype. Homozygous wdb^IP clones have no effect in hair formation or polarity. Homozygous clones cause outgrowths in the wing and eye. wdb^dw/wdb^IP escapers have bald patches on the wing blade where hair formation has either failed or is compromised. The stunted hairs in these regions sometimes have altered polarity.

(Hannus et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wdb[+]/wdb^IP is a suppressor of abnormal body size phenotype of Akt¹/Akt⁰⁴²²⁶

(Vereshchagina et al., 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

wdb^IP has eye phenotype, non-suppressible by Akt¹

(Vereshchagina et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Akt1⁰⁴²²⁶/Akt1¹ flies heterozygous for wdb^IP show a significant increase in body size and weight.

Akt1¹, wdb^IP double mutant eye clones fail to differentiate ommatidia.

(Vereshchagina et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Wdb^IP

(Jia et al., 2009)

wdb^IP

(Su et al., 2011, Wang et al., 2009, Vereshchagina et al., 2008)

wdbIP

(Hannus et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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