FlyBase Allele Report: Dmel\Moe[UAS.Tag:MYC]

General Information

Symbol

Dmel\Moe^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0141662

Feature type

allele

Associated gene

Dmel\Moe

Associated Insertion(s)

Carried in Construct

P{UAS-Moe.myc}

Also Known As

UAS-Myc-Moe⁺, UAS-Myc-Moe, UAS-moe-myc

Key Links

Transgenic product class

cDNA

(Speck et al., 2003)

wild_type

(Speck et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Speck et al., 2003)

wild_type

(Speck et al., 2003)

Mutagen

in vitro construct

(Speck et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-Moe.myc}

Cytology

Description

UASt regulatory sequences drive expression of a full length Moe cDNA tagged with Tag:MYC.

(Speck et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Moe

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

presumptive embryonic salivary gland, with Scer\GAL4^fkh.PH

(Kerman et al., 2008)

Detailed Description

Statement

Reference

Expression of Moe^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096 has no effect on wing morphology.

(Hughes et al., 2010)

Animals expressing Moe^{Scer\UAS.T:Hsap\MYC} in the trachea under the control of Scer\GAL4^btl.PS show wildtype dorsal trunk extension.

Animals expressing Moe^{Scer\UAS.T:Hsap\MYC} in the salivary gland under the control of Scer\GAL4^fkh.PH show a partially-penetrant salivary gland migration defect.

(Kerman et al., 2008)

Ommatidia in flies expressing Moe^{Scer\UAS.T:Hsap\MYC} (under the control of Scer\GAL4^ninaE.PD) are indistinguishable from wild-type controls and present a well organised ommatidium after 7 days illumination.

(Chorna-Ornan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Moe^UAS.Tag:MYC, Scer\GAL4^Bx-MS1096 is an enhancer of visible phenotype of CG10939^EP2037, Scer\GAL4^Bx-MS1096

(Hughes et al., 2010)

NOT Suppressor of

Statement

Reference

Moe^UAS.Tag:MYC/Scer\GAL4^332.3 is a non-suppressor of majority die during embryonic stage phenotype of crb^GX24w-/crb^11A22, crb^Y10A

(Flores-Benitez and Knust, 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Moe^UAS.Tag:MYC, Scer\GAL4^Bx-MS1096 is an enhancer of wing vein phenotype of CG10939^EP2037, Scer\GAL4^Bx-MS1096

(Hughes et al., 2010)

NOT Suppressor of

Statement

Reference

Moe^UAS.Tag:MYC/Scer\GAL4^332.3 is a non-suppressor of embryo | dorsal closure stage phenotype of crb^GX24w-/crb^11A22, crb^Y10A

(Flores-Benitez and Knust, 2015)

Moe^UAS.Tag:MYC/Scer\GAL4^332.3 is a non-suppressor of embryonic/first instar larval cuticle | embryonic stage phenotype of crb^GX24w-/crb^11A22, crb^Y10A

(Flores-Benitez and Knust, 2015)

Other

Statement

Reference

CG10939^EP2037, Moe^UAS.Tag:MYC, Scer\GAL4^Bx-MS1096 has wing blade phenotype

(Hughes et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Moe^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^332.3 fails to suppress the embryonic lethality and dorsal closure defects seen in embryos expressing crb^Y10A in a crb^GX24w-/crb^11A22 background.

(Flores-Benitez and Knust, 2015)

Co-expression of Moe^{Scer\UAS.T:Hsap\MYC} moderately enhances the wing vein defects caused by expression of Sip1^EP2037 under the control of Scer\GAL4^Bx-MS1096 and results in wings that are curved upwards.

(Hughes et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^{Moe-CR00638-TG4.2}/Moe^UAS.Tag:MYC rescues Moe^{CR00638-TG4.2}

(Lee et al., 2018)

Scer\GAL4^T80/Moe^UAS.Tag:MYC rescues Moe^G0323

(Speck et al., 2003)

Partially rescues

Scer\GAL4^en-e16E/Moe^UAS.Tag:MYC partially rescues Moe^G0323