FlyBase Allele Report: Dmel\Pvf2[d02444]

(Bakopoulos et al., 2022, Winkler et al., 2021, Matsubayashi et al., 2017, Choi et al., 2008, Learte et al., 2008, McDonald et al., 2006, Wood et al., 2006, Olofsson and Page, 2005, McDonald et al., 2003, Cho et al., 2002, Munier et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Gli-rL82

(Winkler et al., 2021)

abnormal locomotor behavior | adult stage, with Scer\GAL4^NP2222

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^alrm.PD

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^elav.PLu

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^Gli-rL82

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^GMR14F11

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^GMR83E12

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^GMR90C03

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^moody.SPG

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^NP2222

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^NP3233

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^nrv2.PS

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^nrv2.PS, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^repo, Scer\GAL80^alrm.PS

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^repo, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^repo, Scer\GAL80^nrv2.PR

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW

(Winkler et al., 2021)

increased cell number, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

increased cell number | adult stage, with Scer\GAL4^repo

(Winkler et al., 2021)

increased cell number | P-stage, with Scer\GAL4^repo

(Winkler et al., 2021)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Choi et al., 2008)

lethal, with Scer\GAL4^Tret1.PS

(Winkler et al., 2021)

lethal - all die before end of larval stage, with Scer\GAL4^nSyb.PS

(Winkler et al., 2021)

partially lethal, with Scer\GAL4^NP5130

(Choi et al., 2008)

short lived, with Scer\GAL4^Gli-rL82

(Winkler et al., 2021)

short lived, with Scer\GAL4^NP2222

(Winkler et al., 2021)

short lived, with Scer\GAL4^nrv2.PS

(Winkler et al., 2021)

viable

(Munier et al., 2002)

Phenotype Manifest In

adult central nervous system, with Scer\GAL4^repo

(Winkler et al., 2021)

adult midgut, with Scer\GAL4^NP5130

(Choi et al., 2008)

adult plasmatocyte | adult stage | increased number, with Scer\GAL4^repo

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^alrm.PD

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^elav.PLu

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^Gli-rL82

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^GMR14F11

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^GMR83E12

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^GMR90C03

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^moody.SPG

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^NP2222

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^NP3233

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^nrv2.PS

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^nrv2.PS, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^repo, Scer\GAL80^alrm.PS

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^repo, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^repo, Scer\GAL80^nrv2.PR

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW

(Winkler et al., 2021)

central nervous system, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

embryonic/larval hemocyte, with Scer\GAL4^en-e16E

(Olofsson and Page, 2005)

embryonic/larval hemocyte, with Scer\GAL4^sim.PS

(Wood et al., 2006)

embryonic/larval plasmatocyte | P-stage | increased number, with Scer\GAL4^repo

(Winkler et al., 2021)

enterocyte, with Scer\GAL4^NP5130

(Choi et al., 2008)

enteroendocrine cell | increased number, with Scer\GAL4^NP5130

(Choi et al., 2008)

hemocyte, with Scer\GAL4^btl.PS

(Cho et al., 2002)

intestinal stem cell, with Scer\GAL4^NP5130

(Choi et al., 2008)

larval ventral nerve cord | embryonic stage, with Scer\GAL4^en-e16E

(Olofsson and Page, 2005)

plasmatocyte | increased number, with Scer\GAL4^alrm.PD

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^elav.PLu

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^Gli-rL82

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^GMR14F11

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^GMR83E12

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^GMR90C03

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^moody.SPG

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^NP2222

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^NP3233

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^nrv2.PS

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^nrv2.PS, Scer\GAL80^R90C03.PK

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^repo, Scer\GAL80^alrm.PS

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^repo, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^repo, Scer\GAL80^nrv2.PR

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW

(Winkler et al., 2021)

plasmatocyte | increased number, with Scer\GAL4^repo, Scer\GAL80^Tret1.PW, Scer\GAL80^moody.PZ

(Winkler et al., 2021)

pupal central nervous system, with Scer\GAL4^repo

(Winkler et al., 2021)

Detailed Description

Statement

Reference

The number of proliferating cells in the adult midgut is significantly increased in flies expressing Pvf2^d02444 under the control of Scer\GAL4^esg-NP5130 relative to controls.

The intestinal stem cell population in the midgut of flies expressing Pvf2^d02444 under the control of Scer\GAL4^esg-NP5130 is increased compared to controls. These flies show a 1.4 fold increase in the number of enteroendocrine cells and a 0.7 fold reduction in the number of differentiated enterocytes with large nuclei compared to controls.

(Choi et al., 2008)

Expression of Pvf2^d02444, under the control of Scer\GAL4^slbo.2.6, does not affect border cell migration.

(McDonald et al., 2006)

Expression of Pvf2^d02444 under the control of Scer\GAL4^sim.PS severely disrupts the lateral migrations of hemocytes, such that at stage 15 of development, few hemocytes can be seen occupying more lateral positions. Mutant embryos recover this defect by sage 16, with hemocytes found in the usual three lines running anterior to posterior along the midline.

(Wood et al., 2006)

Expression of Pvf2^d02444, under the control of Scer\GAL4^en-e16E, causes ectopic clumping of hemocytes around the proventriculus and the hindgut of the embryo, which can be observed by stage 15. These mutant hemocytes are never found around the ventral nerve cord (VNC), while in wild-type embryos hemocytes migrate along the sides of this structure during stages 12 to 15. At stage 17, the VNC is shorter in Pvf2^d02444 embryos than in wild-type, indicating that the VNC fails to condense correctly in Pvf2^d02444 mutants.

(Olofsson and Page, 2005)

100% of border cell clusters migrate normally to the oocyte in egg chambers expressing Pvf2^d02444 under the control of Scer\GAL4^Act5C.PI in anterior follicle cell clones. Expression of Pvf2^d02444 under the control of Scer\GAL4^slbo.2.6 does not affect migration of the border cells.

(McDonald et al., 2003)

When Pvf2^d02444 is driven by Scer\GAL4^btl.PS causes misrouting of hemocytes. In many embryos most blood cells are redirected to anteroventral position on around the foregut.

(Cho et al., 2002)

Mutant larvae show no obvious defects in blood cell counts.

(Munier et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

19631

w¹¹¹⁸; P{XP}Pvf2^d02444

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pvf2^XP

(Winkler et al., 2021)

Pvf2^d02444

(Zhang et al., 2013)

Pvf2^d2444

Name Synonyms

Secondary FlyBase IDs

References (12)

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