FlyBase Allele Report: Dmel\e(r)[p2]

General Information

Symbol

Dmel\e(r)^p2

Species

D. melanogaster

Name

FlyBase ID

FBal0141166

Feature type

allele

Associated gene

Dmel\e(r)

Associated Insertion(s)

P{}e(r)^p2

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Roykhman et al., 2007)

Mutagen

Progenitor genotype

Associated Insertion(s)

P{}e(r)^p2

Cytology

Description

Insertion of a 1.1kb P-element in the first exon, upstream of the translation start site. The P-element is oriented in the opposite orientation to the e(r) gene.

(Close and Tsubota, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,906,127..8,906,134 [+]

(Close and Tsubota, 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Close and Tsubota, 2004)

viable

(Roykhman et al., 2007, Close and Tsubota, 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

N^nd-p, e(r)^p2 has lethal phenotype, suppressible by H¹

(Tsubota et al., 2011)

Enhancer of

Statement

Reference

e(r)^p2 is an enhancer of visible phenotype of N^nd-p

(Tsubota et al., 2011)

Other

Statement

Reference

N^nd-1, e(r)^p2 has lethal phenotype

(Tsubota et al., 2011)

N^nd-3, e(r)^p2 has lethal phenotype

(Tsubota et al., 2011)

N^nd-p, e(r)^p2 has lethal phenotype

(Tsubota et al., 2011, Gelsthorpe et al., 2006)

H¹, N^nd-p, e(r)^p2 has viable phenotype

(Tsubota et al., 2011)

N^nd-1, e(r)^p2 has viable phenotype

(Tsubota et al., 2003)

N^nd-3, e(r)^p2 has viable phenotype

(Tsubota et al., 2003)

N^nd-p, e(r)[+]/e(r)^p2 has lethal | dominant phenotype

(Tsubota et al., 2003)

N^nd-p/N[+], e(r)^p2 has lethal | dominant phenotype

(Tsubota et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

e(r)^p2 is an enhancer of wing phenotype of N^nd-p

(Tsubota et al., 2011)

e(r)^p2 is an enhancer of wing phenotype of r^hd1-12

(Close and Tsubota, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The N^nd-p e(r)^p2 combination results in lethality. The few male escapers have severely notched wings.

(Tsubota et al., 2011)

e(r)^p2 N^nd-p flies show synthetic lethality.

(Gelsthorpe et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

e(r)^p2 is rescued by e(r)^+t6.2

(Tsubota et al., 2011)

e(r)^p2 is rescued by e(r)^+t6.2

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T18A

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T18E

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^S24E

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^E27Q

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T63A

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T63E

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T18A.T63A

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^T18E.T63E

(Gelsthorpe et al., 2006)

e(r)^p2 is rescued by e(r)^S24E.T63E

(Gelsthorpe et al., 2006)

Not rescued by

e(r)^p2 is not rescued by e(r)^T18A.S24A

(Gelsthorpe et al., 2006)

e(r)^p2 is not rescued by e(r)^T18E.S24E

(Gelsthorpe et al., 2006)

e(r)^p2 is not rescued by e(r)^{T18A.S24A.T63A}

(Gelsthorpe et al., 2006)

e(r)^p2 is not rescued by e(r)^{T18E.S24E.T63E}

(Gelsthorpe et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

e(r)^p2

(Tsubota et al., 2011, Roykhman et al., 2007, Gelsthorpe et al., 2006, Close and Tsubota, 2004)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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