FlyBase Allele Report: Dmel\Gp150[3]

General Information

Symbol

Dmel\Gp150³

Species

D. melanogaster

Name

FlyBase ID

FBal0138496

Feature type

allele

Associated gene

Dmel\Gp150

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Fetchko et al., 2002)

loss of function allele

(Melnattur et al., 2002)

Mutagen

ethyl methanesulfonate

(Fetchko et al., 2002)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with Gp150^52A)

(Melnattur et al., 2002)

lethal (with Gp150^k11120b)

(Fetchko et al., 2002)

partially lethal - majority die

(Melnattur et al., 2002)

partially lethal - majority die (with Gp150^52A)

(Melnattur et al., 2002)

visible

(Fetchko et al., 2002)

Phenotype Manifest In

anterior scutellar bristle (with Gp150^k11120b)

(Fetchko et al., 2002)

eye

(Fetchko et al., 2002)

eye (with Df(2R)02311)

(Fetchko et al., 2002)

eye (with Gp150⁴)

(Li et al., 2003)

eye (with Gp150^k11120b)

(Fetchko et al., 2002)

eye photoreceptor cell (with Gp150⁴)

(Li et al., 2003)

eye photoreceptor cell | somatic clone

(Li et al., 2003)

ommatidium

(Fetchko et al., 2002)

ommatidium (with Df(2R)02311)

(Fetchko et al., 2002)

ommatidium (with Gp150⁴)

(Li et al., 2003)

ommatidium (with Gp150^k11120b)

(Fetchko et al., 2002)

ommatidium | somatic clone

(Li et al., 2003)

photoreceptor cell R1 (with Gp150^k11120b)

(Fetchko et al., 2002)

photoreceptor cell R6 (with Gp150^k11120b)

(Fetchko et al., 2002)

photoreceptor cell R8 (with Gp150^k11120b)

(Fetchko et al., 2002)

wing margin bristle

(Fetchko et al., 2002)

wing margin bristle | ectopic

(Fetchko et al., 2002)

wing vein L3 | ectopic

(Fetchko et al., 2002)

Detailed Description

Statement

Reference

In Gp150³/Gp150⁴ animals the spacing of ommatidia is abnormal and some ommatidia have fewer or more photoreceptor cells. Mutants have 'rough' eyes. When homozygous clones are made in the eye mutant ommatidia are seen. No specific photoreceptor cell type is found to be mutant at a higher proportion than the others in these clones.

(Li et al., 2003)

45% of ommatidia are mutant in Gp150^k11120b/Gp150³ animals, 29% in Gp150³/Df(2R)02311. Over 60% of Gp150^k11120b/Gp150³ flies fail to develop to adulthood with most of them dying during pupal development. 2/3 of the anterior scutellars in surviving adults, exhibit no shaft and no socket, 1/4 have double sockets, 3% have one shaft and two sockets and another 3% have two shafts and one socket. 45% of ommatidia are mutant in Gp150^k11120b/Gp150³ animals. Developing ommatidial clusters are often irregularly spaced and the morphogenetic furrow appears broader as the cells within the region are no longer constricted in a narrow stripe. Multiple R8 precursor cells are often closely located, about 10% of ommatidia contain multiple R8 precursors that become R8 cells. Some oversized ommatidia are seen at early stages of ommatidia assembly. Some ommatidia contain additional or fewer R1/R6 cells.

(Fetchko et al., 2002)

Approximately 80% of Gp150²/Gp150^52A transheterozygotes survive to adulthood. Females are sterile and fail to lay eggs.

(Melnattur et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Gp150⁴/Gp150³ is a non-enhancer of eye phenotype of sca^BP2

(Li et al., 2003)

Gp150⁴/Gp150³ is a non-enhancer of ommatidium phenotype of sca^BP2

(Li et al., 2003)

Suppressor of

Statement

Reference

Gp150⁴/Gp150³ is a suppressor of wing margin phenotype of Scer\GAL4^dpp.blk1, sca^UAS.cEa

(Li et al., 2003)

NOT Suppressor of

Statement

Reference

Gp150⁴/Gp150³ is a non-suppressor of ommatidium phenotype of sca^BP2

(Li et al., 2003)

Gp150⁴/Gp150³ is a non-suppressor of eye phenotype of sca^BP2

(Li et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Gp150³/Gp150⁴ has no effect on the sca^BP2 eye phenotype When sca^Scer\UAS.cEa is driven by Scer\GAL4^dpp.blk1 in a Gp150⁴/Gp150⁴ background, no wing margin loss is seen..

(Li et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Gp150³

defu³

(Li et al., 2003)

gp1503

(Li et al., 2004)

gp150³

(Melnattur et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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