FlyBase Allele Report: Dmel\comm[UAS.Tag:MYC]

General Information

Symbol

Dmel\comm^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0138290

Feature type

allele

Associated gene

Dmel\comm

Associated Insertion(s)

Carried in Construct

P{UAS-comm.MYC}

Also Known As

UAS-comm

Key Links

Transgenic product class

wild_type

(Keleman et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Keleman et al., 2002)

Mutagen

in vitro construct

(Keleman et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-comm.MYC}

Cytology

Description

UASt sequences drive expression of comm tagged with the Tag:MYC antigen.

(Keleman et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

comm

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

(Keleman et al., 2002)

abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4^ap-md544

(Keleman et al., 2005)

abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of comm^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS results in failure of the 10 dorsal branches of the tracheal system to establish a dorsal anastomosis at the midline.

(Schulz et al., 2011)

Expression of comm^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ap-md544 enables the ipsilateral ap neurons to extend across the midline in most segments of the stage 16 embryo.

Expression of comm^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PLu results in a severe aberrant midline crossing in the stage 16 embryo, with ectopic crossing of FasII neurons in almost every segment.

(Keleman et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has abnormal neuroanatomy | embryonic stage 16 phenotype, non-enhanceable by Nedd4^UAS.Tag:MYC, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has abnormal neuroanatomy | embryonic stage 16 phenotype, non-enhanceable by Nedd4^{CA.UAS.Tag:MYC}, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Enhancer of

Statement

Reference

comm^UAS.Tag:MYC, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Other

Statement

Reference

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC has abnormal neuroanatomy | embryonic stage phenotype

(Gilestro, 2008)

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC, robo1^{UAS.Tag:V5,Tag:polyHis,Tag:HA,Tag:SS(wg)} has abnormal neuroanatomy | embryonic stage phenotype

(Gilestro, 2008)

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC, fra^{UAS.Tag:HA.cGa} has abnormal neuroanatomy | embryonic stage phenotype

(Gilestro, 2008)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^btl.PS, comm^UAS.Tag:MYC has adult dorsal tracheal branch | third instar larval stage phenotype, non-enhanceable by Sdc^RESC.UAS/Scer\GAL4^btl.PS

(Schulz et al., 2011)

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has larval longitudinal connective | embryonic stage 16 phenotype, non-enhanceable by Nedd4^UAS.Tag:MYC, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has commissure | embryonic stage 16 phenotype, non-enhanceable by Nedd4^UAS.Tag:MYC, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has larval longitudinal connective | embryonic stage 16 phenotype, non-enhanceable by Nedd4^{CA.UAS.Tag:MYC}, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Scer\GAL4^elav.PLu, comm^UAS.Tag:MYC has commissure | embryonic stage 16 phenotype, non-enhanceable by Nedd4^{CA.UAS.Tag:MYC}, Scer\GAL4^elav.PLu

(Keleman et al., 2005)

Suppressed by

Statement

Reference

Scer\GAL4^btl.PS, comm^UAS.Tag:MYC has adult dorsal tracheal branch | third instar larval stage phenotype, suppressible | partially by Sdc^RNAi.UAS.cSa/Scer\GAL4^btl.PS

(Schulz et al., 2011)

Enhancer of

Statement

Reference

comm^UAS.Tag:MYC, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Other

Statement

Reference

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC has symmetrical commissure | embryonic stage phenotype

(Gilestro, 2008)

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC, robo1^{UAS.Tag:V5,Tag:polyHis,Tag:HA,Tag:SS(wg)} has symmetrical commissure | embryonic stage phenotype

(Gilestro, 2008)

Scer\GAL4^insc-Mz1407, comm^UAS.Tag:MYC, fra^{UAS.Tag:HA.cGa} has symmetrical commissure | embryonic stage phenotype

(Gilestro, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sdc^{RESC.Scer\UAS} does not enhance the dorsal branch fusion phenotype seen when comm^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^btl.PS in the tracheal system of third instar larvae.

Expression of Sdc^{dsRNA.Scer\UAS.cSa} partially suppresses the dorsal branch fusion phenotype seen when comm^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^btl.PS.

(Schulz et al., 2011)

When fra::robo^{SD.Scer\UAS.T:SV5\V5,T:Zzzz\His6,T:Ivir\HA1,T:SS-wg} and comm^{Scer\UAS.T:Hsap\MYC} are co-expressed under the control of Scer\GAL4^insc-Mz1407 the axons collapse into the midline.

When robo^{Scer\UAS.T:SV5\V5,T:Zzzz\His6,T:Ivir\HA1,T:SS-wg} and comm^{Scer\UAS.T:Hsap\MYC} are co-expressed under the control of Scer\GAL4^insc-Mz1407 the axons collapse into the midline.

When fra^{Scer\UAS.T:Ivir\HA1.cGa} and comm^{Scer\UAS.T:Hsap\MYC} are co-expressed under the control of Scer\GAL4^insc-Mz1407 the axons collapse into the midline.

(Gilestro, 2008)

Expression of Nedd4^{Scer\UAS.T:Hsap\MYC} does not enhance the aberrant midline crossing phenotype seen when comm^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^elav.PLu in stage 16 embryos.

Expression of Nedd4^{CA.Scer\UAS.T:Hsap\MYC} does not suppress the aberrant midline crossing phenotype seen when comm^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^elav.PLu in stage 16 embryos.

(Keleman et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

comm^UAS.Tag:MYC/Scer\GAL4^Poxn.14 partially rescues comm⁰⁷²

(Keleman et al., 2005)

comm^UAS.Tag:MYC, comm^sli.Tag:MYC, Scer\GAL4^Poxn.14 partially rescues comm⁰⁷²

(Keleman et al., 2005)

comm^sim.Tag:MYC, comm^UAS.Tag:MYC, Scer\GAL4^Poxn.14 partially rescues comm⁰⁷²

(Keleman et al., 2005)

Comments

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos. At least one midline crossing occurs correctly in 67% of the segments.

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14, with expression of comm in the midline using comm^{sli.T:Hsap\MYC}, partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14, with expression of comm in the midline using comm^{sim.T:Hsap\MYC}, partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

(Keleman et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

66891

P{UAS-comm.MYC}1, w^*

66887

y¹ w^*; P{UAS-comm.MYC}2

Notes on Origin

Discoverer