FB2024_03 , released June 25, 2024
Allele: Dmel\SdcKG06163
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General Information
Symbol
Dmel\SdcKG06163
Species
D. melanogaster
Name
FlyBase ID
FBal0137351
Feature type
allele
Associated gene
Dmel\Sdc
Associated Insertion(s)
P{SUPor-P}SdcKG06163
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}SdcKG06163
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous show a significant reduction in bouton number at the neuromuscular junction compared to wild type.

      (Johnson et al., 2006)

      Around 7% of SdcKG06163 mutants show an ISNb bypass phenotype.

      (Fox and Zinn, 2005)

      SdcKG06163 embryos show a low frequency of axons crossing the midline in the central nervous system.

      (Johnson et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      SaraUbi.PJ, Sdc48/SdcKG06163 has abnormal neuroanatomy | larval stage phenotype, enhanceable by Lar5.5/Lar[+]

      (Johnson et al., 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      SaraUbi.PJ, Sdc48/SdcKG06163 has NMJ bouton | larval stage phenotype, enhanceable by Lar5.5/Lar[+]

      (Johnson et al., 2006)
      Enhancer of
      Statement
      Reference

      SdcKG06163 is an enhancer of anterior fascicle & axon | ectopic phenotype of Larbypass

      (Fox and Zinn, 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Lar5.5/+ enhances the reduction in bouton number at the neuromuscular junction which is seen in SdcKG06163/Df(2R)48 larvae (carrying SaraUbi.PJ to provide Sara function).

      (Johnson et al., 2006)

      SdcKG06163 increases the penetrance of the Larbypass ISNb bypass phenotype by more than 2-fold.

      (Fox and Zinn, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SdcKG06163
      (Bokel et al., 2006)
      SdcKG
      (Johnson et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)