FB2024_03 , released June 25, 2024
Allele: Dmel\exexJJ154
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General Information
Symbol
Dmel\exexJJ154
Species
D. melanogaster
Name
FlyBase ID
FBal0137269
Feature type
allele
Associated gene
Dmel\exex
Associated Insertion(s)
Carried in Construct
Also Known As
hb9JJ154
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Broihier and Skeath, 2002)
Mutagen
ethyl methanesulfonate
(Broihier and Skeath, 2002)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1589A.

(Broihier and Skeath, 2002)

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 32 amino acids.

(Broihier and Skeath, 2002)

Amino acid replacement: W?term.

(Broihier and Skeath, 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:7,950,847..7,950,847 [+]
Nucleotide change:

G7950847A

Reported nucleotide change:

G1589A

Amino acid change:

W494term | exex-PA

Reported amino acid change:

W?term

(Broihier and Skeath, 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      68.3% of exexKK30/exexJJ154 mutant anterior dMP2 neurons fail to undergo apoptosis. Other aspects of dMP2 specification appear unaffected; they are able to project neurons posteriorly along the most medial fascicle, and exit the VNC to innervate the hindgut correctly.

      (Miguel-Aliaga et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      exexJJ154/exexKK30 is rescued by exexUAS.cOa/Scer\GAL4odd-106

      (Miguel-Aliaga et al., 2008)
      Not rescued by

      exexJJ154/exexKK30 is not rescued by exexUAS.cOa/Scer\GAL4Vap.P0201

      (Miguel-Aliaga et al., 2008)
      Comments

      Expression of exexScer\UAS.cOa from embryonic stage 16 onwards under the control of Scer\GAL4Vap.P0201 fails to rescue the apoptosis defects seen in exexKK30/exexJJ154 mutant anterior dMP2 neurons. Expressing exexScer\UAS.cOa from stage 10 under the control of Scer\GAL4odd-106 does rescue this apoptosis.

      (Miguel-Aliaga et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      exex protein is present at wild type levels.

      (Broihier and Skeath, 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      dHb9JJ154
      (Broihier and Skeath, 2002)
      exexJJ154
      exexjj154
      (Lacin et al., 2014)
      hb9JJ154
      (Miguel-Aliaga et al., 2008, Broihier et al., 2004)
      hb9jj154
      (Lacin et al., 2009)
      hb9jj154e
      (Santiago et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)