FlyBase Allele Report: Dmel\Dg[EP2241]

General Information

Symbol

Dmel\Dg^EP2241

Species

D. melanogaster

Name

FlyBase ID

FBal0131267

Feature type

allele

Associated gene

Dmel\Dg

Associated Insertion(s)

P{EP}Dg^EP2241

Carried in Construct

Also Known As

EP(2)2241

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Deng et al., 2003, Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}Dg^EP2241

Cytology

Description

Insertion 330bp downstream of the transcription start site.

(Takeuchi et al., 2009)

Insertion in the first non-coding exon.

(Christoforou et al., 2008)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,098,207..16,098,207 [-]

(Takeuchi et al., 2009, Christoforou et al., 2008, Deng et al., 2003, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal thermotaxis | third instar larval stage

(Takeuchi et al., 2009)

abnormal thermotaxis | third instar larval stage (with Dg^atu)

(Takeuchi et al., 2009)

visible

(Christoforou et al., 2008)

Phenotype Manifest In

posterior crossvein

(Christoforou et al., 2008)

Detailed Description

Statement

Reference

Dg^EP2241 mutant larvae raised at 25[o]C show a strong temperature preference that peaks at 18.3[o]C on a linear thermal gradient ranging from 12[0] to 35[o]C, in contrast to wild-type larvae which have a temperature preference peak of 22.1[o]C in this assay.

Dg^atu/Dg^EP2241 larvae raised at 25[o]C show a strong temperature preference that peaks at 17.6[o]C on a linear thermal gradient ranging from 12[0] to 35[o]C.

(Takeuchi et al., 2009)

Homozygotes have a weakly penetrant posterior crossvein defect. Frequent branching of the crossvein is seen, either alone, or in combination in a "gapped" phenotype (where the crossvein is detached from either vein L4 or L5, but not both).

(Christoforou et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The "EP(2)2241" line was originally homozygous lethal in stock, but outcrossing yields homozygous viable lines.

(Christoforou et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dg²²⁴¹

(Christoforou et al., 2008)

Dg^EP2241

EP(2)2241

(Deng et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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