FB2024_03 , released June 25, 2024
Allele: Dmel\Gβ13FΔ1-96A
Open Close
General Information
Symbol
Dmel\Gβ13FΔ1-96A
Species
D. melanogaster
Name
FlyBase ID
FBal0128192
Feature type
allele
Associated gene
Dmel\Gβ13F
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Schaefer et al., 2001)
Mutagen
P-element activity
(Schaefer et al., 2001)
Progenitor genotype
Gβ13FEP1071
(Schaefer et al., 2001)
Cytology
Description

Imprecise excision of the P{EP} element removing the entire coding region and extending 1867bp downstream of the transcription unit.

(Schaefer et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mesoderm invagination is delayed (mesoderm breadth is significantly reduced) and posterior midgut is variably affected (the anterior movement of pole cells due to posterior midgut invagination and tissue extension is defective) in Gβ13FΔ1-96A/Gβ13FΔ1-96A embryos (germline clones) compared to controls.

      (Kerridge et al., 2016)

      Gβ13FΔ1-96A/+ larval neuromuscular junctions show no significant change in bouton number in comparison to wild-type neuromuscular junctions.

      (Bogdanik et al., 2004)

      Embryos derived from homozygous female germline clones show morphological defects during gastrulation which lead to the formation of anterior and posterior holes in the cuticle. Neuroblasts delaminate normally and enter mitosis shortly after delamination in these embryos. Only 26% of the asymmetric cell divisions in the mutant neuroblasts are oriented along the apical-basal axis (as occurs in wild type), other divisions are misoriented by more than 30 degrees.

      (Schaefer et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Gbeta13F[+]/Gβ13FΔ1-96A, mGluR112b has bouton phenotype

      (Bogdanik et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Gβ13F/+ background suppresses the increase in synaptic bouton number seen when mGluRAScer\UAS.cRa is expressed under the control of Scer\GAL4OK6 in a wild-type background.

      mGluRA112b/+; Gβ13FΔ1-96A/+ double mutant larvae show an increase in synaptic bouton size that is not seen in either single mutant heterozygote. The bouton number is not changed in the double mutants.

      (Bogdanik et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gβ13FΔ1-96A is rescued by Gβ13F+tSa

      (Schaefer et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gb13FD1-96A
      (Boyle and Berg, 2007)
      Gβ13F 1-96A
      (Fuse et al., 2003)
      Gβ13FΔ1-96A
      (Li et al., 2021, Kerridge et al., 2016, Nurminsky, 2007, Bogdanik et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)