FB2024_03 , released June 25, 2024
Allele: Dmel\dachs210
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General Information
Symbol
Dmel\dachs210
Species
D. melanogaster
Name
FlyBase ID
FBal0127240
Feature type
allele
Associated gene
Dmel\dachs
Associated Insertion(s)
Carried in Construct
Also Known As
d210
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Katz, 2001.12.11)
Progenitor genotype
Cytology
Description

Amino acid replacement: R912term.

(Mao et al., 2006)

A point mutation that results in a stop codon in the active thiol region of the d protein.

(Mao et al., 2006)

Point mutation resulting in a stop codon in the myosin head domain.

(Katz, 2001.12.11)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,487,120..8,487,120 [+]
Nucleotide change:

C8487120T

Amino acid change:

R924term | d-PD; R1106term | d-PE

Reported amino acid change:

R912term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bosveld et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      d210/dGC13 transheterozygotes display some hair orientation defects in the posterior dorsal abdomen, as compared to controls.

      (Misra and Irvine, 2016)

      d1/d210 adult wings show ectopic crossveins but lack the anterior crossvein.

      The legs of dGC13/d210 flies are smaller than wild-type legs.

      (Mao et al., 2006)

      d210 somatic clones in the wing induced 24-48 or 48-72 hours after egg laying are nor recoverable in late third instar wing discs, even when they are given a growth advantage using the Minute technique.

      (Cho and Irvine, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      dachs210/d[+] is an enhancer of visible phenotype of fjN7

      (Buckles et al., 2001)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      dachs210/d[+] is an enhancer of leg joint phenotype of fjN7

      (Buckles et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      dachs210/dachsGC13 is rescued by dachsGFP

      (Bosveld et al., 2012)

      dachs210/dachsGC13 is rescued by dachs+tcBa

      (Bosveld et al., 2012)
      Comments

      dT:Avic\GFP rescues the morphological defects and viability of dGC13/d210 animals.

      d+tcBa rescues the morphological defects and viability of dGC13/d210 animals.

      (Bosveld et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Although d210 mutants die by early larval stages, this is probably due to a separable mutation on the chromosome as other d alleles with more severe phenotypes survive to the end of pupal development.

      (Mao et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      d210
      (Bosveld et al., 2016, Misra and Irvine, 2016, Mao et al., 2006)
      dachs210
      (Nagai et al., 2021, Arata et al., 2017)
      dachs<up>210</up>
      (Bosveld et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)