FlyBase Allele Report: Dmel\faf[EP3520]

General Information

Symbol

Dmel\faf^EP3520

Species

D. melanogaster

Name

FlyBase ID

FBal0125065

Feature type

allele

Associated gene

Dmel\faf

Associated Insertion(s)

P{EP}faf^EP3520

Carried in Construct

Also Known As

EP(3)3520

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Wing et al., 2002, DiAntonio et al., 2001, Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}faf^EP3520

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:31,776,983..31,776,983 [+]

(Koch et al., 2017, Kim et al., 2010, Zhao et al., 2008, Wing et al., 2002, DiAntonio et al., 2001, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(DiAntonio et al., 2001)

abnormal neuroanatomy | larval stage, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

abnormal neuroanatomy | pharate adult stage, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

abnormal neurophysiology, with Scer\GAL4^elav-C155

(DiAntonio et al., 2001)

Phenotype Manifest In

bouton | increased number, with Scer\GAL4^elav-C155

(DiAntonio et al., 2001)

embryonic/larval central nervous system, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

neurite | pharate adult stage, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

synapse | increased number, with Scer\GAL4^elav-C155

(DiAntonio et al., 2001)

synaptic vesicle, with Scer\GAL4^elav-C155

(DiAntonio et al., 2001)

Detailed Description

Statement

Reference

Expression of faf^EP3520 under the control of Scer\GAL4^Ccap.PP results in subtle defects in small portions of the central nervous system arbor in larvae.

Expression of faf^EP3520 under the control of Scer\GAL4^Ccap.PP results in the loss of adult-specific neurite projections.

(Zhao et al., 2008)

When faf^EP3520 is driven by Scer\GAL4^elav-C155, a marked expansion in the size and complexity is seen in the synapses. There is an increase in both the number of synaptic boutons and in the synaptic span. There is also an increase in the number of synaptic branches. When the evoked excitatory junctional potentials (EJPs) of faf^EP3520, Scer\GAL4^elav-C155 embryos are examined, a marked reduction is seen in their amplitudes. A large decrease in quantal content is also seen, and the frequency of spontaneous mEJPs is also reduced.

(DiAntonio et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

faf^EP3520 is a suppressor of visible phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Other

Statement

Reference

Scer\GAL4^GMR.PF, faf^EP3520, grim::rpr^rg.UAS has lethal phenotype

(Wing et al., 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

faf^EP3520 is a suppressor of eye phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

faf^EP3520 enhances the rough eye phenotype seen when Dcp-1^Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4^GMR.PF.

(Kim et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

FAF^EP3520

(Lee et al., 2012)

faf^EP3520

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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