FlyBase Allele Report: Dmel\Cdc42[L89.UAS]

General Information

Symbol

Dmel\Cdc42^L89.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0123294

Feature type

allele

Associated gene

Dmel\Cdc42

Associated Insertion(s)

Carried in Construct

P{UAS-Cdc42.L89}

Key Links

Transgenic product class

dominant_negative_variant

(Baron et al., 2000)

missense_variant

(Luo, 2001.5.2)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Baron et al., 2000)

missense_variant

(Luo, 2001.5.2)

Mutagen

in vitro construct

(Baron et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Cdc42.L89}

Cytology

Description

Amino acid replacement: S89L.

(Luo, 2001.5.2)

A dominant negative form of Cdc42 is expressed under the control of UAS regulatory sequences.

(Baron et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Cdc42

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

microchaeta, with Scer\GAL4^ptc-559.1

(Baron et al., 2000)

wing, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

wing hair, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

wing hair | ectopic, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

wing margin, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

wing margin bristle, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Baron et al., 2000)

Detailed Description

Statement

Reference

Expression of Cdc42^L89.Scer\UAS driven by Scer\GAL4^ptc-559.1 results in loss or stunting of epidermal hairs. When Cdc42^L89.Scer\UAS is driven by Scer\GAL4^Bx-MS1096, occasional multiple (but still stunted) wing hairs are seen. A reduction in wing size, formation of ectopic vein tissue and wing margin phenotypes. A strong bristle loss phenotype is seen in the wing margin which precludes observation of the width of the margin stripe. Small outgrowths in the wing surface are also seen.

(Baron et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Eip78C^EP3468, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by NFAT^EP1335, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by NFAT^EP1353, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by lilli^EP1211, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Tlk^EP1408, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Tlk^EP1413, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by NFAT^EP1390, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by NFAT^EP1508, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Tao^EP1455, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by bol^EP3659, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by dco^EP3280, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Enhanced by

Statement

Reference

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10433^EP2034, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG10433^EP2516, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CG1090^EP3028, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Amun^EP1503, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CHES-1-like^EP1342, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by CHES-1-like^EP1453, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Dlc90F^EP3634, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Dsp1^EP355, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1200^EP1200, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1207^EP1207, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP1340^EP1340, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP2204^EP2204, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP2444^EP2444, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by EP712^EP712, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by HmgD^EP467, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by MESR4^EP988, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Smg5^EP2171, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tim10^EP2421, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tim10^EP541, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Tsp42Ef^EP2571, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by ago^EP1135, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by ball^EP863, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by robo2^EP2582, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Sar1^EP3575, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by skd^EP3443, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Ip6k^EP2310, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by tou^EP622, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Ip6k^EP2319, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Ip6k^EP2440, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Prp40^EP719, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Isha^EP2258, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Atg1^EP3348, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Suppressed by

Statement

Reference

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Ip6k^EP436, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT suppressed by

Statement

Reference

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Atg1^EP3348, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Ip6k^EP2310, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CHES-1-like^EP1342, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CHES-1-like^EP1453, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dlc90F^EP3634, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dsp1^EP355, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1200^EP1200, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1207^EP1207, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP1340^EP1340, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP2204^EP2204, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP2444^EP2444, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by EP712^EP712, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Ip6k^EP2319, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by HmgD^EP467, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by MESR4^EP988, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Smg5^EP2171, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tim10^EP2421, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tim10^EP541, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Tsp42Ef^EP2571, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by ago^EP1135, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by ball^EP863, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by robo2^EP2582, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Sar1^EP3575, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Ip6k^EP2440, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by skd^EP3443, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by tou^EP622, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10433^EP2034, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG10433^EP2516, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG1090^EP3028, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Amun^EP1503, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Prp40^EP719, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Cdc42^L89.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Isha^EP2258, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

6289

w^*; P{UAS-Cdc42.L89}4

Kyoto

108722

w^*; P{UAS-Cdc42.L89}4

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cdc42^L89.Scer\UAS

Cdc42^L89.UAS

cdc42^L89

(Zhu et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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