FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp10DEP1172
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General Information
Symbol
Dmel\Ptp10DEP1172
Species
D. melanogaster
Name
FlyBase ID
FBal0123124
Feature type
allele
Associated gene
Dmel\Ptp10D
Associated Insertion(s)
P{EP}Ptp10DEP1172
Carried in Construct
Also Known As
EP(X)1172
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kraut et al., 2001, Kraut et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{EP}Ptp10DEP1172
Cytology
Description

The P{EP} element is inserted within the 5' UTR.

(Kraut et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and Ptp10Dchi/Ptp10DEP1172 flies show significantly lower 1 day memory after spaced training compared to control flies.

      Homozygous flies show normal 1 day memory after massed training.

      (Qian et al., 2007)

      Mutant larvae expressing Ptp10DEP1172 under the control of Scer\GAL4elav-C155 have reduced or abnormal synapses. Mutant larvae expressing Ptp10DEP1172 under the control of Scer\GAL4elav-C155 have ISN neuron pathfinding defects.

      (Kraut et al., 2001)

      Mutant larvae expressing Ptp10DEP1172 under the control of Scer\GAL4elav-C155 display a strong phenotype in which ISNb axons separate from each other after leaving the ISN and ander over the surfaces of the muscle fibres.

      (Kraut et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Ptp10DEP1172, Ptp4EKG02328 has lethal phenotype

      (Jeon et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Cysts are seen in the ganglionic branches and the diameter of the ganglionic branches is larger than normal in Ptp4E1 Ptp10DEP1172 double mutant embryos.

      (Jeon and Zinn, 2009)

      Ptp4EKG02328, Ptp10DEP1172/Y double mutant animals do not survive to adulthood.

      (Jeon et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Ptp10Dchi

      (Qian et al., 2007)
      Comments

      Expression of Ptp10DEP1172 under the control of Scer\GAL4btl.PS completely rescues the tracheal defects of Ptp4E1 Ptp10DEP1172 double mutant embryos.

      (Jeon and Zinn, 2009)

      Driving Ptp10DEP1172 in tracheae with Scer\GAL4btl.PS in a Ptp4E1 Ptp10DEP1172 background rescues lethality, allowing some adults to emerge.

      (Jeon et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp10DEP1172
      (Taniguchi and Igaki, 2023, Lee et al., 2013, Jeon and Zinn, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)