FB2024_03 , released June 25, 2024
Allele: Dmel\Nrg180.UAS
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General Information
Symbol
Dmel\Nrg180.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0122043
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Nrg180
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS sequences drive expression of the Nrg[180] neural-specific isoform.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Nrg180.Scer\UAS driven by Scer\GAL4Tab2-201Y does not affect pruning of mushroom body γ neurons.

Expression of Nrg180.Scer\UAS using Scer\GAL4179Y results in viable larvae that hatch normally and do not show cephalopharyngeal skeleton alterations.

Flies expressing Nrg180.Scer\UAS using Scer\GAL4Bx-MS1096 at 25[o]C show a reduction in the proximal-distal axis of the wing, though no reduction of intervein territory or splitting/fusion of veins is observed.

Expression of Nrg180.Scer\UAS pre-synaptically, under the control of Scer\GAL4c17 results in 77% rescue of the physiological Nrg849 mutant phenotype.

Expression of Nrg180.Scer\UAS post-synaptically, under the control of Scer\GAL4shakB.lethal.4.1 in a Nrg849 mutant background results in a 70% rescue of the physiological Nrg849 mutant phenotype.

Expression of Nrg180.Scer\UAS pre- and post-synaptically, under the control of Scer\GAL4shakB.lethal.4.1 in a Nrg849 mutant background results in complete (100%) rescue of the physiological Nrg849 mutant phenotype.

Overexpression of one or more copies of Nrg180.Scer\UAS under the control of Scer\GAL4c17, Scer\GAL4shakB.lethal.4.1, or Scer\GAL4A307, pre-, post-synaptically, or both, in a wild-type background has no disruptive effect on the giant synapse anatomically or physiologically.

Scer\GAL4MS1075-driven expression of neural-Nrg180.Scer\UAS in the ocellar sensory system of control individuals does not cause a phenotype in BM axons and only occasionally, some OP axons erroneously extend on the epidermis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of bskDN.Scer\UAS.cUa with Nrg180.Scer\UAS driven by Scer\GAL4Tab2-201Y results in mushroom body γ lobe pruning defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Scer\GAL4MS1075-driven expression of neural-Nrg180.Scer\UAS in Nrgl3 mutant animals rescues both the pentrance and the expressivity of the OP and BM axon misguidance defects.

The addition of Nrg180.Scer\UAS to Nrgl10 flies rescues the ocellar pioneer (OP) axon alterations, but not the stalling and misprojection phenotypes of the bristle mechanosensory (BM) axons.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nrg180.Scer\UAS
Nrg180.UAS
Name Synonyms
Secondary FlyBase IDs
    References (6)