Expression of Nrg180.Scer\UAS driven by Scer\GAL4Tab2-201Y does not affect pruning of mushroom body γ neurons.
Expression of Nrg180.Scer\UAS using Scer\GAL4179Y results in viable larvae that hatch normally and do not show cephalopharyngeal skeleton alterations.
Flies expressing Nrg180.Scer\UAS using Scer\GAL4Bx-MS1096 at 25[o]C show a reduction in the proximal-distal axis of the wing, though no reduction of intervein territory or splitting/fusion of veins is observed.
Expression of Nrg180.Scer\UAS pre-synaptically, under the control of Scer\GAL4c17 results in 77% rescue of the physiological Nrg849 mutant phenotype.
Expression of Nrg180.Scer\UAS post-synaptically, under the control of Scer\GAL4shakB.lethal.4.1 in a Nrg849 mutant background results in a 70% rescue of the physiological Nrg849 mutant phenotype.
Expression of Nrg180.Scer\UAS pre- and post-synaptically, under the control of Scer\GAL4shakB.lethal.4.1 in a Nrg849 mutant background results in complete (100%) rescue of the physiological Nrg849 mutant phenotype.
Overexpression of one or more copies of Nrg180.Scer\UAS under the control of Scer\GAL4c17, Scer\GAL4shakB.lethal.4.1, or Scer\GAL4A307, pre-, post-synaptically, or both, in a wild-type background has no disruptive effect on the giant synapse anatomically or physiologically.
Scer\GAL4MS1075-driven expression of neural-Nrg180.Scer\UAS in the ocellar sensory system of control individuals does not cause a phenotype in BM axons and only occasionally, some OP axons erroneously extend on the epidermis.
Nrg180.UAS, Scer\GAL4Tab2-201Y, bskDN.UAS.cUa has abnormal neuroanatomy phenotype
Nrg180.UAS, Scer\GAL4Tab2-201Y, bskDN.UAS.cUa has axon phenotype
Co-expression of bskDN.Scer\UAS.cUa with Nrg180.Scer\UAS driven by Scer\GAL4Tab2-201Y results in mushroom body γ lobe pruning defects.
Scer\GAL4MS1075/Nrg180.UAS partially rescues Nrgl10
Scer\GAL4MS1075-driven expression of neural-Nrg180.Scer\UAS in Nrgl3 mutant animals rescues both the pentrance and the expressivity of the OP and BM axon misguidance defects.
The addition of Nrg180.Scer\UAS to Nrgl10 flies rescues the ocellar pioneer (OP) axon alterations, but not the stalling and misprojection phenotypes of the bristle mechanosensory (BM) axons.