FB2024_03 , released June 25, 2024
Allele: Dmel\Cdk1E51Q
Open Close
General Information
Symbol
Dmel\Cdk1E51Q
Species
D. melanogaster
Name
FlyBase ID
FBal0121834
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E51Q.

    (Tio et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:10,385,642..10,385,642 [-]
    Nucleotide change:

    G10385642C

    Amino acid change:

    E51Q | Cdk1-PA

    Reported amino acid change:

    E51Q

    (Tio et al., 2001)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes show late embryonic lethality and show various abnormalities (like those seen in insc and raps mutants) which can be explained by defects in asymmetric divisions. 14% of GMC4-2a cells fail to divide and differentiate into a "large" RP2 neuron. 33% of GMC4-2a cells divide symmetrically (unlike in wild type) and give rise to two RP2s with equal nuclear size. Misorientation of the mitotic spindle is seen in GMC4-2a and in neuroblasts. Duplication of muscle DA1 can be seen. Strong RP2 neuron phenotypes are only seen in cdc2E51Q/Df(2L)J3 embryos if the cdc2E51Q allele is inherited from the mother (and not if it is inherited from the father).

        (Tio et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        cdc2[+]/Cdk1E51Q is a suppressor of increased cell death phenotype of shtd1

        (Tanaka-Matakatsu et al., 2007)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        cdc2[+]/Cdk1E51Q is a suppressor of eye phenotype of shtd1

        (Tanaka-Matakatsu et al., 2007)

        cdc2[+]/Cdk1E51Q is a suppressor of ommatidium phenotype of shtd1

        (Tanaka-Matakatsu et al., 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Cdk1E51Q
        cdc2E51Q
        (Tanaka-Matakatsu et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)