FB2024_03 , released June 25, 2024
Allele: Dmel\Cdk1UAS.cWa
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General Information
Symbol
Dmel\Cdk1UAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Weigmann
FlyBase ID
FBal0065868
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
P{UAS-Cdk1.W}
Also Known As
UAS-Cdk1
Key Links
Transgenic product class
cDNA
(Weigmann et al., 1997)
wild_type
(Weigmann et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Weigmann et al., 1997)
wild_type
(Weigmann et al., 1997)
Mutagen
in vitro construct
(Weigmann et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-Cdk1.W}
Cytology
Description

A Cdk1 cDNA is expressed under the control of UASt regulatory sequences.

(Weigmann et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cdk1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cdc2E1-24 flies raised at the restrictive temperature from pupariation onwards and expressing cdc2Scer\UAS.cWa under the control of Scer\GAL4en-e16E do not eclose, but the pattern of vein and intervein regions is normal 30 hours after shifting to the restrictive temperature. The anterior compartment of the wing disc is normal in size, but is composed of fewer and larger cells compared to the posterior compartment. cdc2E1-24 larvae in which cdc2Scer\UAS.cWa is expressed under the control of Scer\GAL4en-e16E shortly after the moult to third instar and then the larvae are raised at the restrictive temperature of 30oC have wing discs with fewer but very much larger cells in the anterior compartment compared to the posterior compartment.

      (Weigmann et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Cdk1UAS.cWa, Scer\GAL4ey.PH is a suppressor of eye phenotype of Mmus\Shisa5UAS.cGa, Scer\GAL4ey.PH

      (Gupta et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of cdc2Scer\UAS.cWa suppresses the eye phenotypes seen when Mmus\Shisa5Scer\UAS.cGa is expressed under the control of Scer\GAL4dpp.PH.

      (Gupta et al., 2008)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Cdk1Scer\UAS.cWa
      Cdk1UAS.cWa
      cdc2Scer\UAS.cWa
      cdc2UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Weigmann
      (Weigmann et al., 1997)
      Secondary FlyBase IDs
        References (5)