FB2024_03 , released June 25, 2024
Allele: Dmel\vir22
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General Information
Symbol
Dmel\vir22
Species
D. melanogaster
Name
FlyBase ID
FBal0121495
Feature type
allele
Associated gene
Dmel\vir
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
diepoxybutane
(Niessen et al., 2001)
X ray
(Niessen et al., 2001)
Progenitor genotype
Cytology
Description

295bp deletion associated with a 2bp insertion, resulting in a frameshift. The protein produced contains 1261 amino acids of the wild-type conceptual translation product (which is 1854 amino acids long), followed by a short stretch of amino acids.

(Niessen et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:23,361,999..23,362,294 [-]
Inserted_sequence:

NN

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Mutation is a 295 bp deletion after amino acid 1261 which leads to a frameshift and a truncated protein. Mutation is also associated with a 2bp insertion.

(Niessen et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      XX and XY homozygotes do not survive.

      (Niessen et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      vir2f/vir22 is a suppressor of lethal | male phenotype of SxlM1

      (Niessen et al., 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      vir22 is rescued by vir+t10

      (Niessen et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that can suppress (in trans with vir2f) the male-specific lethality of SxlM1.

      (Niessen et al., 2001)
      Comments
      Comments

      "diepoxybutane" was stated as tentative. "X ray" was stated as tentative.

      (Niessen et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vir22
      Name Synonyms
      Secondary FlyBase IDs
        References (1)