FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)RC-ΔASE
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General Information
Symbol
Dmel\Su(H)RC-ΔASE
Species
D. melanogaster
Name
FlyBase ID
FBal0120611
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
P{Su(H)RC-ΔASE}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Barolo et al., 2000)
Progenitor genotype
Su(H)+t6.0
(Barolo et al., 2000)
Carried in construct
P{Su(H)RC-ΔASE}
Cytology
Description

Construct: Deletion of the Autoregulatory Socket Enhancer (ASE) sequences from downstream of the Su(H) gene.

(Barolo et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Su(H)_RC-DeltaASE
Encoded product / tool
Su(H)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The mean transepithelial potential (TEP) and mechanoreceptor potential (MRP) of mechanosensory bristles of flies carrying Su(H)RC-ΔASE in a Su(H)unspecified background are reduced compared to wild type. The mechanoreceptor current (MRC) is also reduced compared to wild type. A clearly identifiable tormogen cell is evident in the mutant bristles. Flies carrying two copies of Su(H)RC-ΔASE in a wild-type background do not have a double-socket bristle phenotype.

      (Barolo et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Su(H)2 Sox154AA/Su(H)8 Sox154AA; Su(H)RC-ΔASE mutants show a more dramatic socket differentiation defect than either single mutant. Most of the double mutant bristles have a convex (rather than concave) socket-shaft cuticular interface. Dome of these bulbous socket structures extend one or more small cuticular projections, while others extend one or two distinctly shaft-like structures.

      (Miller et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Su(H)RC-ΔASE rescues Su(H)unspecified

      (Barolo et al., 2000)
      Comments

      Su(H)unspecified flies carrying one copy of Su(H)RC-ΔASE are viable and fertile and more than 99.5% of macrochaetae are wild type. A low frequency of double shafts and missing bristles (less than 0.5% combined) is seen.

      (Barolo et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(H)RC-ΔASE
      Name Synonyms
      Secondary FlyBase IDs
        References (3)