FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)+t6.0
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General Information
Symbol
Dmel\Su(H)+t6.0
Species
D. melanogaster
Name
FlyBase ID
FBal0042755
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
P{Su(H)+6.0}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Schweisguth and Posakony, 1992)
wild_type
(Schweisguth and Posakony, 1992)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Schweisguth and Posakony, 1992)
wild_type
(Schweisguth and Posakony, 1992)
Mutagen
in vitro construct
(Schweisguth, 1995, Schweisguth et al., 1994, Schweisguth and Posakony, 1992)
Progenitor genotype
Carried in construct
P{Su(H)+6.0}
Cytology
Description

A 6.0kb XbaI EcoRI genomic fragment, extending from coordinate +10 to +16, contains ~650bp upstream of the presumed start site of Su(H) transcription as well as at least 1kb of 3' flanking sequence. In addition CIAPIN1 transcription unit is truncated 59bp downstream of the apparent start site and encodes the very 3' end of ck transcripts.

(Schweisguth and Posakony, 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Su(H)_+10/+16
Encoded product / tool
Su(H)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:15,038,788..15,045,274 [+]
Linked to:
XbaI-EcoRI restriction fragment
Comment:

position of restriction fragment on reference sequence inferred by FlyBase curator

(Schweisguth and Posakony, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The transepithelial potential (TEP) and mechanoreceptor potential (MRP) of mechanosensory bristles of flies carrying Su(H)+t6.0 in a Su(H)unspecified background is normal. The mechanoreceptor current (MRC) is normal. Flies carrying six copies of Su(H)+t6.0 in a wild-type background show double-socket bristles (flies carrying two copies of Su(H)+t6.0 in a wild-type background never show this phenotype).

      (Barolo et al., 2000)

      Cells at the border of a clone expressing four copies of Su(H) show a bias to adopting an epidermal fate.

      (Schweisguth, 1995)

      High copy numbers of this Su(H)+ allele cause double socket phenotype similar to that produced by H hypomorphic alleles. In addition, those specific macrochaetae that are most sensitive to the loss of H function fail to appear.

      (Schweisguth and Posakony, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Su(H)+t6.0 is an enhancer of phenotype of H2

      (Schweisguth and Posakony, 1992)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Su(H)+t6.0 rescues Su(H)IB115

      (Schweisguth et al., 1994)

      Su(H)+t6.0 rescues Su(H)unspecified

      (Schweisguth and Posakony, 1992)

      Su(H)+t6.0 rescues Su(H)8/Su(H)2

      (Schweisguth and Posakony, 1992)
      Comments

      One copy of P{Su(H)+6.0} rescues the imaginal disc neurogenic phenotype and recessive pupal lethality of strong loss of function alleles. Also the imaginal discs of Su(H)8/Su(H)2 heterozygotes have a wild type pattern of single sensory organ precursors (SOPs) and the adults are fully viable and wild type in phenotype. The dominant suppression of H2 double socket phenotype by Su(H)8 can be alleviated by one copy of P{Su(H)+6.0}.

      (Schweisguth and Posakony, 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(H)+t6.0
      Name Synonyms
      Secondary FlyBase IDs
        References (6)