FB2024_03 , released June 25, 2024
Allele: Dmel\stgEP3432
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General Information
Symbol
Dmel\stgEP3432
Species
D. melanogaster
Name
FlyBase ID
FBal0119133
Feature type
allele
Associated gene
Dmel\stg
Associated Insertion(s)
P{EP}stgEP3432
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bidet et al., 2003, McGovern et al., 2003, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{EP}stgEP3432
Cytology
Description

P{EP} insertion 421bp upstream of the stg translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of stg.

(Bidet et al., 2003)

Inserted 37bp upstream from the start of the hkb first exon.

(McGovern et al., 2003)

P{EP} insertion in antisense orientation relative to the transcription unit.

(Abdelilah-Seyfried et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTV337M.UAS
      (Shulman and Feany, 2003)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ventral nerve cord commissures in stage 17 stgEP3432; Scer\GAL4sca-4512 embryos are fused.

      (McGovern et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      stgEP3432/Scer\GAL4sca-537.4 is a non-enhancer of phenotype of HE21

      (Abdelilah-Seyfried et al., 2000)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      stgEP3432/Scer\GAL4sca-537.4 is a non-suppressor of phenotype of HE21

      (Abdelilah-Seyfried et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is suppressed by stgEP3432.

      (Shulman and Feany, 2003)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

      (Pena-Rangel et al., 2002)
      Comments
      Comments

      Precise excision of the P{EP} element reverts the modifying effect of stgEP3432 on the rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF.

      (Shulman and Feany, 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EP(3)3432
      (Abdelilah-Seyfried et al., 2000)
      stgEP3432
      Name Synonyms
      Secondary FlyBase IDs
        References (6)