FlyBase Allele Report: Dmel\Inx2[UAS.cSa]

General Information

Symbol

Dmel\Inx2^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Stebbings

FlyBase ID

FBal0118191

Feature type

allele

Associated gene

Dmel\Inx2

Associated Insertion(s)

Carried in Construct

P{UAS-Inx2.S}

Also Known As

UAS-inx2

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Stebbings et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Inx2.S}

Cytology

Description

UASt regulatory sequences drive expression of a 1.5kb EcoRI fragment of Inx2 EST LD11362.

(Stebbings et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Inx2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal, with Scer\GAL4^arm.PS

(Stebbings et al., 2000)

partially lethal, with Scer\GAL4^how-24B

(Stebbings et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of inx2^Scer\UAS.cSa under the control of Scer\GAL4^how-24B results in similar hatch rates as controls, but only 15% of the total number of embryos survive to adulthood. Expression of inx2^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS results in reduced survival rates compared to controls.

(Stebbings et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Inx2^UAS.cSa, Scer\GAL4^how-24B has lethal phenotype, enhanceable by Inx3^UAS.cSa, Scer\GAL4^how-24B

(Stebbings et al., 2000)

Other

Statement

Reference

Inx2^UAS.cSa, Inx3^UAS.cSa, Scer\GAL4^arm.PS has lethal phenotype

(Stebbings et al., 2000)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of inx2^Scer\UAS.cSa and inx3^Scer\UAS.cSa under the control of Scer\GAL4^how-24B results in significantly lower viability than when inx2^Scer\UAS.cSa alone is expressed under the control of Scer\GAL4^how-24B; only 27% of embryos hatch and only 5.5% reach adulthood. Co-expression of inx2^Scer\UAS.cSa and inx3^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS results in reduced survival rates compared to controls.

(Stebbings et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Inx2^Scer\UAS.cSa

Inx2^UAS.cSa

inx2^Scer\UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Stebbings

(Stebbings et al., 2000)

Secondary FlyBase IDs

References (2)

Report Sections

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