FlyBase Allele Report: Dmel\Inx3[UAS.cSa]

General Information

Symbol

Dmel\Inx3^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Stebbings

FlyBase ID

FBal0118190

Feature type

allele

Associated gene

Dmel\Inx3

Associated Insertion(s)

Carried in Construct

P{UAS-Inx3.S}

Key Links

Transgenic product class

cDNA

(Stebbings et al., 2000)

wild_type

(Stebbings et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Stebbings et al., 2000)

wild_type

(Stebbings et al., 2000)

Mutagen

in vitro construct

(Stebbings et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Inx3.S}

Cytology

Description

UASt regulatory sequences drive expression of Inx3 EST LD17559.

(Stebbings et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Inx3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased size | adult stage, with Scer\GAL4^eya.PB

(Richard et al., 2017)

visible | adult stage, with Scer\GAL4^eya.PB

(Richard et al., 2017)

Phenotype Manifest In

eye, with Scer\GAL4^eya.PB

(Richard et al., 2017)

Detailed Description

Statement

Reference

Expression of inx3^Scer\UAS.cSa under the control of Scer\GAL4^how-24B results in similar hatch and eclosion rates as controls.

(Stebbings et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Inx3^UAS.cSa, Scer\GAL4^how-24B is an enhancer of lethal phenotype of Inx2^UAS.cSa, Scer\GAL4^how-24B

(Stebbings et al., 2000)

NOT Suppressor of

Statement

Reference

Inx3^UAS.cSa, Scer\GAL4^eya.PB is a non-suppressor of decreased size | adult stage phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Inx3^UAS.cSa, Scer\GAL4^eya.PB is a non-suppressor of visible | adult stage phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Inx3^UAS.cSa/ogre^UAS.Tag:MYC, Scer\GAL4^eya.PB is a non-suppressor of decreased size | adult stage phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Inx3^UAS.cSa/ogre^UAS.Tag:MYC, Scer\GAL4^eya.PB is a non-suppressor of visible | adult stage phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Other

Statement

Reference

Inx2^UAS.cSa, Inx3^UAS.cSa, Scer\GAL4^arm.PS has lethal phenotype

(Stebbings et al., 2000)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Inx3^UAS.cSa, Scer\GAL4^eya.PB is a non-suppressor of eye phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Inx3^UAS.cSa/ogre^UAS.Tag:MYC, Scer\GAL4^eya.PB is a non-suppressor of eye phenotype of Inx2^RNAi.UAS.WIZ, Scer\GAL4^eya.PB

(Richard et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of inx2^Scer\UAS.cSa and inx3^Scer\UAS.cSa under the control of Scer\GAL4^how-24B results in significantly lower viability than when inx2^Scer\UAS.cSa alone is expressed under the control of Scer\GAL4^how-24B; only 27% of embryos hatch and only 5.5% reach adulthood. Co-expression of inx2^Scer\UAS.cSa and inx3^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS results in reduced survival rates compared to controls.

(Stebbings et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Inx3^UAS.cSa/Scer\GAL4^eya.PB rescues Inx3^RNAi.UAS.WIZ

(Richard et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Inx3^Scer\UAS.cSa

Inx3^UAS.cSa

inx3^Scer\UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Stebbings

(Stebbings et al., 2000)

Secondary FlyBase IDs

References (2)

Report Sections

Open Close