FB2024_03 , released June 25, 2024
Allele: Dmel\prosV17
Open Close
General Information
Symbol
Dmel\prosV17
Species
D. melanogaster
Name
FlyBase ID
FBal0105095
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
P{?GawB}prosV17
Carried in Construct
Also Known As
Voila17
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Grosjean et al., 2003)
Mutagen
Delta2-3 transposase
(Grosjean et al., 2001, Balakireva et al., 2000)
Progenitor genotype
prosV1
(Grosjean et al., 2001, Balakireva et al., 2000)
Associated Insertion(s)
P{?GawB}prosV17
Cytology
Description

prosV17 may include a large deletion of the pros coding region in addition to the complete excision of the P{GawB}prosV1 insertion.

(Grosjean et al., 2003)

Imprecise excision of the P{GawB} element.

(Balakireva et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The median lifespan for prosV17 animals (the age after egg laying at which 50% of homozygotes have died) is 0.59 days at 25oC.

      (Grosjean et al., 2003)

      The courtship index of heterozygous males towards decapitated Canton-S males is significantly higher than that of wild-type males towards decapitated Canton-S males. The courtship index of heterozygous males towards decapitated Canton-S males is significantly lower than that of heterozygous prosV1 males towards decapitated Canton-S males.

      (Grosjean et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      pros[+]/prosV17 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of dpn7/dpn1

      (Zhu et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      pros[+]/prosV17 is a suppressor | partially of type I neuroblast | third instar larval stage phenotype of dpn7/dpn1

      (Zhu et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      prosV17/+ partially rescues the reduction in number of type I neuroblasts which is seen in the brains of late third larval instar dpn1/dpn7 larvae.

      (Zhu et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      pros17

      (Grosjean et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Voila17
      (Grosjean et al., 2001, Balakireva et al., 2000)
      prosV17
      (Grosjean et al., 2003)
      prosv17
      (Zhu et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)