FlyBase Allele Report: Dmel\pins[Δ50]

General Information

Symbol

Dmel\pins^Δ50

Species

D. melanogaster

Name

FlyBase ID

FBal0104949

Feature type

allele

Associated gene

Dmel\pins

Associated Insertion(s)

Carried in Construct

Also Known As

pins^Δ1-50

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schaefer et al., 2000)

Progenitor genotype

P{EP}EP3559

(Schaefer et al., 2000)

Cytology

Description

An excision of P{EP}wdb^EP3559 that also removes at least the start codon of raps.

(Schaefer et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Katanaev and Tomlinson, 2006)

abnormal mitotic cell cycle (with pins¹⁹³)

(Katanaev and Tomlinson, 2006)

viable

(Schaefer et al., 2000)

Phenotype Manifest In

spindle

(Schaefer et al., 2000)

wing margin

(Katanaev and Tomlinson, 2006)

wing margin (with pins¹⁹³)

(Katanaev and Tomlinson, 2006)

Detailed Description

Statement

Reference

Animals homozygous for raps^Δ50 exhibit only rare defects in asymmetric divisions in the wing margin. raps^Δ50/raps¹⁹³ transheterozygous mutants exhibit extensive asymmetric division phenotypes in all tissues analysed. These phenotypes can be rescued through expression of the raps^hs.PP transgene.

(Katanaev and Tomlinson, 2006)

In mutant pI cells, like the wild-type, no rotation is observed in late metaphase.

(Bellaiche et al., 2001)

In mutant embryos, 33% of neuroblast show apical-basal spindle orientation (compared to 70% in wild-type).

(Schaefer et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

pins^Δ50 has abnormal mitotic cell cycle phenotype, enhanceable by Gαo^UAS.cKa/Scer\GAL4^Bx-MS1096

(Katanaev and Tomlinson, 2006)

Enhancer of

Statement

Reference

raps[+]/pins^Δ50 is an enhancer of abnormal cell polarity phenotype of Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Katanaev and Tomlinson, 2006)

Other

Statement

Reference

pins[+]/pins^Δ50, wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Phenotype Manifest In

Other

Statement

Reference

pins[+]/pins^Δ50, wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in wts^x1/+;pins^Δ50/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

(Keder et al., 2015)

Overexpression of G-oα47A^Scer\UAS.cKa, under the control of Scer\GAL4^Bx-MS1096 in a raps^Δ50 heterozygous background results in a significant enhancement of the asymmetric division defects observed in G-oα47A^Scer\UAS.cKa Scer\GAL4^Bx-MS1096 mutants.

(Katanaev and Tomlinson, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

pins^Δ50 is rescued by pins^hs.PP

(Katanaev and Tomlinson, 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

pins^Δ1-50

(Bellaiche et al., 2001, Schaefer et al., 2001)

pins^Δ50

(Keder et al., 2015, Katanaev and Tomlinson, 2006, Schaefer et al., 2000)

raps^Δ50

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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