FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp69DH24
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General Information
Symbol
Dmel\Ptp69DH24
Species
D. melanogaster
Name
FlyBase ID
FBal0104729
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Newsome et al., 2000)
Mutagen
ethyl methanesulfonate
(Newsome et al., 2000)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G to A. Amino acid replacement: G1105R. Mutation replaces an invariant Gly residue flanking the active site of the first phosphatase domain.

(Newsome et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,739,550..12,739,550 [+]
Nucleotide change:

G12739550A

Reported nucleotide change:

G?A

Amino acid change:

G1105R | Ptp69D-PA; G1104R | Ptp69D-PB

Reported amino acid change:

G1105R

(Newsome et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      medulla | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R1 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R2 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R3 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R4 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R5 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R6 & axon | somatic clone

      (Newsome et al., 2000)

      photoreceptor cell R7 & axon | somatic clone

      (Newsome et al., 2000)
      Detailed Description
      Statement
      Reference

      Photoreceptor fates are correctly specified, but their axons project abnormally into the optic lobes in homozygous clones in the eye. Some of the axons of R1-R6, which normally terminate in the lamina, instead continue through the lamina to terminate in the medulla, terminating at the same level as either the R8 or R7 axons. Frequent gaps in the array of R7 axon termini in the medulla are seen. 47% of R7 axons fail to reach their normal target layer in the medulla (although the R7 cell is missing in only 1% of ommatidia). Approximately 70% of R7 axons terminate prematurely within the medulla at the same level as the R8 axons.

      (Newsome et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      H24
      (Newsome et al., 2000)
      Ptp69DH24
      Y125
      (Desai and Purdy, 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)