FlyBase Allele Report: Dmel\smg[1]

General Information

Symbol

Dmel\smg¹

Species

D. melanogaster

Name

FlyBase ID

FBal0102400

Feature type

allele

Associated gene

Dmel\smg

Associated Insertion(s)

Carried in Construct

Also Known As

smaug¹

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Dahanukar et al., 1999)

Mutagen

ethyl methanesulfonate

(Dahanukar et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates oculopharyngeal muscular dystrophy

modeled by Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

exacerbates myotonic dystrophy type 1

modeled by Zzzz\CTG^i480.UAS

(de Haro et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

smg¹/Df(3L)Scf-R6 third instar larvae show a reduction in the density of terminal dendritic branches of the class IV da neurons.

(Brechbiel and Gavis, 2008)

Embryos derived from hemizygous females arrest very early in embryonic development. Nuclear divisions appear essentially indistinguishable from wild type from fertilisation through cycle 10. However, beginning in cycle 11, the pattern of nuclei becomes increasingly irregular, with a variety of defects including asynchronous mitoses and "gaps" in the otherwise regular array of nuclei at the surface of the embryo. The proportion of mitotic nuclei suggests that progression through mitosis is retarded. The terminal phenotype appears to result from the aggregation of nuclei that fall from the surface into the middle of the embryo. The embryos never achieve the nuclear density seen at the surface of wild-type cycle 14 embryos and fail to cellularise.

(Dahanukar et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

smg[+]/smg¹ is a suppressor of visible phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

Other

Statement

Reference

smg[+]/smg¹, twin^GS8115 has lethal | dominant | maternal effect | embryonic stage phenotype

(Zaessinger et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

smg[+]/smg¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS

(de Haro et al., 2013)

smg[+]/smg¹ is an enhancer of eye phenotype of Hsap\CELF1^UAS.cdHa, Scer\GAL4^GMR.PU

(de Haro et al., 2013)

NOT Enhancer of

Statement

Reference

smg[+]/smg¹ is a non-enhancer of eye phenotype of Hsap\MBNL1^{UAS.Tag:Xpress}, Scer\GAL4^GMR.PU

(de Haro et al., 2013)

Suppressor of

Statement

Reference

smg[+]/smg¹ is a suppressor of wing phenotype of Hsap\PABPN1^17ala.Act88F

(Chartier et al., 2015)

NOT Suppressor of

Statement

Reference

smg[+]/smg¹ is a non-suppressor of eye phenotype of Hsap\MBNL1^{UAS.Tag:Xpress}, Scer\GAL4^GMR.PU

(de Haro et al., 2013)

smg¹ is a non-suppressor of wing phenotype of Scer\GAL4^sca-109-68, nanos^{αTub84B.3'UTR.nanos+2.UAS}

(Clark et al., 2002)

smg¹ is a non-suppressor of adult cuticle phenotype of Scer\GAL4^sca-109-68, nanos^{αTub84B.3'UTR.nanos+2.UAS}

(Clark et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

smg¹ glo^162x double mutant larvae do not show a more severe phenotype in the class IV da neurons than either single mutant.

(Brechbiel and Gavis, 2008)

Embryos derived from twin^GS8115 smg¹ double heterozygotes show 32% lethality, whereas embryos derived from either single mutant do not show maternal effect lethality.

(Zaessinger et al., 2006)

The frequency of the adolescent phenotype in animals expressing nos^{αTub84B.3'UTR.nos+2.Scer\UAS} under the control of Scer\GAL4^sca-109-68 is not altered if they are also carrying smg¹.

(Clark et al., 2002)

Xenogenetic Interactions

Statement

Reference

smg¹ suppresses the wing posture defects seen upon expression of Hsap\PABPN1^17ala.Act88F.

(Chartier et al., 2015)

Complementation and Rescue Data

Complements

smg^DocA

(Reim et al., 2003)

smg^DocB

(Reim et al., 2003)

Rescued by

smg¹ is rescued by smg^ΔC

(Dahanukar et al., 1999)

smg¹ is rescued by smg^+t13.5

(Dahanukar et al., 1999)

Not rescued by

smg¹ is not rescued by smg^RBD

(Dahanukar et al., 1999)

smg¹ is not rescued by smg^ΔRBD

(Dahanukar et al., 1999)

Comments

smg^DocA and smg^DocB complement the female sterility associated with smg¹.

(Reim et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5930

smg¹/TM3, Sb¹

Notes on Origin

Discoverer

Separable from: a second site lethal mutation on the chromosome.

(Brechbiel and Gavis, 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

smaug¹

(Chen et al., 2014, Pinder and Smibert, 2013)

smg

(Dahanukar et al., 1999)

smg¹

(Siddiqui et al., 2024, Chartier et al., 2015, de Haro et al., 2013, Rouget et al., 2010, Brechbiel and Gavis, 2008, Sofola et al., 2007, Tadros et al., 2007, Zaessinger et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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