FB2024_03 , released June 25, 2024
Allele: Dmel\ttvunspecified
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General Information
Symbol
Dmel\ttvunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0102366
Feature type
allele
Associated gene
Dmel\ttv
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous embryos show a defect in germ cell migration.

        Stage 13 embryos derived from homozygous female germline clones mated to wild-type males (these embryos lack maternal but not zygotic ttv+ function) show a range of germ cell migration defects. In some cases, a subset of germ cells fail to coalesce, while in other cases, most of the germ cells have scattered. More than 40% of the embryos have five or more "lost" germ cells that have failed to coalesce with the somatic gonadal precursor cells (less than 5% of wild-type embryos have this many "lost" germ cells).

        (Deshpande et al., 2007)

        No defects in mesoderm migration are seen in mutant embryos. The invaginating stomatogastric nervous system appears normal.

        (The et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        ttv[+]/ttvunspecified is an enhancer of germline cell phenotype of hhMrt

        (Deshpande et al., 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        ttvunspecified dominantly enhances the severity of the mild germ cell migration defects seen in hhMrt heterozygous embryos.

        (Deshpande et al., 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        ttvunspecified is rescued by ttvUAS.Tag:MYC/Scer\GAL4unspecified

        (The et al., 1999)
        Comments

        The segment polarity phenotype of ttvunspecified embryos is rescued by ttvScer\UAS.T:Hsap\MYC expressed under the control of Scer\GAL4unspecified.

        (The et al., 1999)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ttvunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)