FlyBase Allele Report: Dmel\Smg5[EP2171]

General Information

Symbol

Dmel\Smg5^EP2171

Species

D. melanogaster

Name

FlyBase ID

FBal0101519

Feature type

allele

Associated gene

Dmel\Smg5

Associated Insertion(s)

P{EP}Smg5^EP2171

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Kraut et al., 2001, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Progenitor genotype

Associated Insertion(s)

P{EP}Smg5^EP2171

Cytology

Description

P{EP} insertion within the first exon.

(Ashburner et al., 1999)

P{EP} insertion at position 3159 of DS08220, in the first exon 5bp upstream of the first intron.

(Ashburner et al., 1999.10.12)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:13,904,403..13,904,403 [+]

(Zhu et al., 2005, Gene Disruption Project members, 2001-, Kraut et al., 2001, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

viable

(Ashburner et al., 1999)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

Mutant larvae expressing Smg5^EP2171 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing Smg5^EP2171 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

No obvious phenotype.

(Ashburner et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Smg5^EP2171, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF