FlyBase Allele Report: Dmel\Plc21C[k31911]

General Information

Symbol

Dmel\Plc21C^k31911

Species

D. melanogaster

Name

FlyBase ID

FBal0100413

Feature type

allele

Associated gene

Dmel\Plc21C

Associated Insertion(s)

P{lacW}Plc21C^k31911

Carried in Construct

Also Known As

Plc21C^P319

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Weinkove et al., 1999, Heisenberg, 1998.11.4)

Progenitor genotype

Associated Insertion(s)

P{lacW}Plc21C^k31911

Cytology

Description

Insertion into first intron of the Plc21C transcription unit.

(Weinkove et al., 1999)

P{lacW} insertion is just to the left of the alternatively spliced exon of Plc21C.

(Heisenberg, 1998.11.4)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology (with Plc21C^A)

(Kain et al., 2008)

abnormal neurophysiology | dominant

(Kain et al., 2008)

abnormal neurophysiology | recessive

(Badsha et al., 2012)

abnormal smell perception (with Df(2L)Pi3K21B-A)

(Badsha et al., 2012)

abnormal smell perception | recessive

(Badsha et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Temperature preferences of Plc21C^k31911 homozygous mutant late third instar larvae are unchanged compared to wild-type controls.

(Sokabe et al., 2016)

Plc21C^k31911 homozygotes and Plc21C^k31911/Df(2L)Pi3K21B-A transheterozygotes show decreased avoidance to CO2, as compared to heterozygous and wild-type controls; in agreement, both mutants show decreased electrophysiological responses of the basiconica rich region of the 3rd antennal segment to CO2 exposure, as compared to controls. These homozygotes do not exhibit changes in the number of ab1C neurons.

(Badsha et al., 2012)

The electroantennograms of Plc21C^k31911/+ animals show a small but significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate).

The electroantennograms of Plc21C^k31911/Plc21C^A and Plc21C^k31911/Plc21C^k31911 animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate).

(Kain et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Plc21C^k31911 has abnormal neurophysiology | dominant phenotype, enhanceable by Galpha49B[+]/Gαq^221c

(Kain et al., 2008)

Plc21C^k31911 has abnormal neurophysiology | dominant phenotype, enhanceable by Gα49B[+]/Gαq¹³⁷⁰

(Kain et al., 2008)

Suppressed by

Statement

Reference

Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361, Plc21C^k31911/Plc21C[+] has flightless | partially phenotype, suppressible by Ca-P60A[+]/SERCA^Kum170

(Banerjee et al., 2006)

Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361, Plc21C^k31911/Plc21C[+] has abnormal neurophysiology phenotype, suppressible by Ca-P60A[+]/SERCA^Kum170

(Banerjee et al., 2006)

Enhancer of

Statement

Reference

Plc21C^k31911/Plc21C[+] is an enhancer of abnormal neurophysiology | dominant phenotype of Gαq^221c

(Kain et al., 2008)

Plc21C^k31911/Plc21C[+] is an enhancer of abnormal neurophysiology | dominant phenotype of Gαq¹³⁷⁰

(Kain et al., 2008)

Plc21C^k31911/Plc21C[+] is an enhancer of flightless | partially phenotype of Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361

(Banerjee et al., 2006)

Other

Statement

Reference

Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361, Plc21C^k31911/Plc21C[+] has partially lethal - majority die phenotype

(Banerjee et al., 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361, Plc21C^k31911/Plc21C[+] has wing phenotype, suppressible by Ca-P60A[+]/SERCA^Kum170

(Banerjee et al., 2006)

Enhancer of

Statement

Reference

Plc21C^k31911/Plc21C[+] is an enhancer of wing phenotype of Gα49B[+]/Gαq^221c, Itpr^wc703/Itpr^wc361

(Banerjee et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The electroantennograms of Gα49B^221c/Plc21C^k31911 and Gα49B¹³⁷⁰/Plc21C^k31911 double heterozygous animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate) and the reduction in the double heterozygotes is significantly greater than that expected to arise from a mere additive effect of the single heterozygous phenotypes.

(Kain et al., 2008)

The reduced viability, abnormal wing posture, flight behaviour defects and increased spontaneous firing at NMJs seen in Itp-r83A^wc703/Itp-r83A^wc361; Gα49B^221c/+ are enhanced by Plc21C^k31911/+. These phenotypes are largely suppressed if Ca-P60A^Kum170/+ is also present.

(Banerjee et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced with: mbm^k31911.

(Weinkove et al., 1999, Heisenberg, 1998.11.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

319/11

(Heisenberg, 1998.11.4)

P319/11

(Aravamudan and Broadie, 2003)

Plc21C^P319/11

(Banerjee et al., 2006)

Plc21C^P319

(Banerjee et al., 2006)

Plc21C^k31911

Plcβ21C^P319

(Banerjee et al., 2006)

plc21C^P319

(Li et al., 2020, Kain et al., 2008)

plc21c^P319

(Sokabe et al., 2016, Badsha et al., 2012, Kain et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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