FB2024_03 , released June 25, 2024
Allele: Dmel\ciCe-2.UAS.Tag:HA
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General Information
Symbol
Dmel\ciCe-2.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0097033
Feature type
allele
Associated gene
Dmel\ci
Associated Insertion(s)
Carried in Construct
P{UAS-ci.Ce-2.HA}
Also Known As
UAS-Cicell, CiCell
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Methot and Basler, 1999)
Progenitor genotype
Carried in construct
P{UAS-ci.Ce-2.HA}
Cytology
Description

ciCe-2 tagged at the N terminus with Tag:HA is expressed under the control of UASt regulatory sequences.

(Methot and Basler, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ci
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Continuous overexpression of the repressor isoform ci[Ce-2.Scer\UAS. T:Ivir \HA1] from larval stages into the adult driven by Scer\GAL4byn-Gal4 in combination with Scer\GAL80ts.αTub84B results in a markedly shortened hindgut that consists almost entirely of small, undifferentiated cells normally found only in the hindgut proliferation zone in the wild-type.

      (Takashima et al., 2008)

      In the eye discs of ciCe-2.Scer\UAS.T:Ivir\HA1; Scer\GAL4fng-B animals, furrow progression and differentiation fails in ventral cells, but is normal in dorsal regions of the eye. However, ciU.Scer\UAS.T:Ivir\HA1; Scer\GAL4h-H10 flies have normal eyes.

      (Fu and Baker, 2003)

      Expression of ciCe-2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act5C.PP in somatic clones in the ovary can result in multicyst and apposed egg chambers, disorganised encapsulation in the germarium and abnormal stalk formation.

      (Besse et al., 2002)

      Clones of anterior cells in the wing disc expressing ciCe-2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act5C.PP take up positions normally occupied only by posterior cells and define straight borders to anterior cells which do not carry ciCe-2.Scer\UAS.T:Ivir\HA1.

      (Dahmann and Basler, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The suppression of the WGMR.PG eye phenotype seen in eyes mosaic for cosH29 (generated using the ey-FLP/FRT system) is reverted by expression of ciCe-2.Scer\UAS.T:Ivir\HA1 (via the MARCM system) in the cosH29 clones.

      (Christiansen et al., 2013)

      Expression of ciCe-2.Scer\UAS.T:Ivir\HA1 does not suppress the dendrite pruning defects seen in ddaC neurons expressing lin19GD9650 under the control of Scer\GAL4ppk.PG at 16 hours after pupariation.

      (Wong et al., 2013)

      When ciCe-2.Scer\UAS.T:Ivir\HA1 and eyScer\UAS.cHa co-expressed (driven by Scer\GAL4Act5C.PI) in clones in the wing disc, morphogenetic furrow initiation and photoreceptor differentiation are blocked within the clones. When ciCe-2.Scer\UAS.T:Ivir\HA1 and hhScer\UAS.cAa co-expressed (driven by Scer\GAL4bi-omb-Gal4) in the wing disc leads to overgrowth and ectopic morphogenetic furrow initiation.

      (Kango-Singh et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CiCell
      (Nellas et al., 2022)
      ciCe-2.Scer\UAS.T:Ivir\HA1
      ciCe-2.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (19)