FB2024_03 , released June 25, 2024
Allele: Dmel\btl::tor4021.UAS
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General Information
Symbol
Dmel\btl::tor4021.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0094564
Feature type
allele
Associated gene
btl::tor
Associated Insertion(s)
Carried in Construct
P{UAS-torso4021-btl}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Vincent et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-torso4021-btl}
Cytology
Description

A chimeric construct consisting of the extracellular domain of the constitutively active tor13D mutant fused to the intracellular domain of btl is expressed under the control of UAS regulatory sequences.

(Vincent et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
btl::tor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      btl::tor4021.Scer\UAS Scer\GAL4αTub84B.PL somatic clones in the dorsal air sac primordium are larger than wild-type clones, forming bulky outgrowths. These clones never contribute to the primordium tip but show extremely dynamic cytoskeletal activity - forming large lamellopodia which extend away from the air sac, simlar to cells at the tip. (clones generated by Scer\GAL80 MARCM technique.)

      (Cabernard and Affolter, 2005)

      Flies expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4Bx-MS1096 have larger wings than normal, with extra wing vein material and deltas at the wing margin.

      (Feldmann et al., 1999)

      Embryos expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in a wild-type background show excessive terminal branching in the tracheal system.

      (Vincent et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      btl::tor4021.UAS/Scer\GAL4btl.PS is a non-suppressor of phenotype of stumps09904b

      (Vincent et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing phenotype see in flies expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4Bx-MS1096 is suppressed by coexpression of vapScer\UAS.T:Hsap\MYC.

      (Feldmann et al., 1999)

      Expression of btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in btlLG19 mutant embryos partially rescues tracheal cell migration, and additional tracheal branching is seen, as in embryos expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in a wild-type background. Expression of btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in stumps09904b mutant embryos does not rescue tracheal migration defects.

      (Vincent et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      btl::tor4021.Scer\UAS
      btl::tor4021.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)