Dendrites develop normally in sensory neurons (C4da) of IKKε¹/IKKε¹ larval clones.

IKKε¹ mutants display abnormal bristle morphology, wherein bristles are short and branched.

Dendritic severing is strongly inhibited in homozygous ddaC neuron clones at 20 hours after puparium formation (APF), with most proximal dendrites remaining intact at this stage in the mutant cells (proximal dendrites can be seen disconnected from the ddaC soma at 5 hours APF in wild-type animals).

Apoptosis occurs normally in l(2)38Ea³⁶/l(2)38Ea⁶⁶ embryos.

At low temperature and in uncrowded culture conditions, rare escaper ik2¹ adults (<1%) are observed, but they die shortly after eclosion. These escapers often exhibit abnormal bristles, both the interommatidial and the humeral bristles are affected. At high magnification, the actin footprints along the length of the bristle shaft in ik2¹ escaper adult eyes appears less organised than those in wild-type bristles. In wild-type, interommatidial bristles are found at alternating vertices, whereas in ik2¹ mutants these bristles are often duplicated at a single vertex and are misshapen and kinked.

More than 95% of the embryos laid by ik2¹ mutant females do not hatch; however, larval cuticle preparations indicate that the embryos aren't dorsalised. The majority of embryos display a bic-like phenotype, ranging from headless embryos to embryos with a duplicated abdomen in place of the head and thorax. In addition to this anteroposterior patterning defect, a large number of embryos from ik2¹ germ-line clones exhibit expanded ventral cuticular structures.

Embryos from ik2¹ germ-line clones are both ventralised and bicaudal, exhibiting a variable phenotype, with expanded ventral denticle bands and filzkorper (a posterior structure) in both the tail and the anterior of the embryo. Approximately 47% of the embryos produced from ik2¹ mutant females are bicaudal, with the remainder of the embryos appearing ventralised with a range of phenotypes that included expanded and disorganised ventral denticle belts, ventral holes, and a reduced dorsal cuticle.

The majority of eggs produced by ik2¹ germ-line clones have a single fused dorsal appendage (as oppose to two, in wild-type), and some lack dorsal appendages all together.

At stage 8-9, ik2¹ mutant egg chambers are indistinguishable from wild-type. At stage 9, a subpopulation of microtubules are disrupted in ik2¹ mutants.

Microtubule minus-ends are not properly distributed at the anterior of ik2¹ mutant oocytes during mid-oogenesis.

At stage 7, in oocytes dervied from females containing ik2¹ germ-line clones, ectopic sites of actin polymerisation are visible.