FlyBase Allele Report: Dmel\Btk[e482]

General Information

Symbol

Dmel\Btk^e482

Species

D. melanogaster

Name

FlyBase ID

FBal0090758

Feature type

allele

Associated gene

Dmel\Btk

Associated Insertion(s)

Carried in Construct

Also Known As

Tec29^e482

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Guarnieri et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: W491term.

(Guarnieri et al., 1998)

Nucleotide substitution: G1473A.

(Guarnieri et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:8,260,970..8,260,970 [-]

Nucleotide change:

G8260970A

Reported nucleotide change:

G1473A|FBrf0102812

Amino acid change:

Reported amino acid change:

W491term

(Guarnieri et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Guarnieri et al., 1998)

Phenotype Manifest In

egg

(Guarnieri et al., 1998)

nurse cell ring canal

(Guarnieri et al., 1998)

presumptive embryonic salivary gland

(Chandrasekaran and Beckendorf, 2005)

Detailed Description

Statement

Reference

Btk29A^e482 embryos exhibit abnormally long salivary glands that do not fully invaginate. Cell counting and monitoring of mitoses show that the long glands are not the result of recruitment of extra cells into the salivary gland primordium or from the production of extra cells during development.

(Chandrasekaran and Beckendorf, 2005)

Females with homozygous germ line clones have defects in ring canal morphogenesis, and show a failure to completely transfer the cytoplasmic contents of the nurse cells to the oocyte. These females produce eggs ranging in size from 50% to 100% of wild-type.

(Guarnieri et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Btk^e482 is an enhancer of semi-sterile phenotype of Src64B^Δ17

(Guarnieri et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Btk^e482 is an enhancer of nurse cell ring canal phenotype of Src64B^Δ17

(Guarnieri et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Modestly enhances the fertility defect of Src64B^Δ17 homozygotes. Markedly reduces the ring canal size of Src64B^Δ17 homozygotes. Expression of Btk29A^hs.2sev reverses the effect of Btk29A^e482 on Src64B^Δ17 egg chambers.

(Guarnieri et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Btk^k05610

(Guarnieri et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: Dominant enhancer of the infertility phenotype of Src64B^Δ17 homozygotes.

(Guarnieri et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Btk29A^e482

Btk^e482

E(Src64)2A^e482

(Guarnieri et al., 1998)

Tec29^e482

(Chandrasekaran and Beckendorf, 2005, Guarnieri et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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