FB2024_03 , released June 25, 2024
Allele: Dmel\dockW48K.UAS
Open Close
General Information
Symbol
Dmel\dockW48K.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0089346
Feature type
allele
Associated gene
Dmel\dock
Associated Insertion(s)
Carried in Construct
P{UAS-dock.W48K}
Key Links
Transgenic product class
missense_variant
(Rao and Zipursky, 1998)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rao and Zipursky, 1998)
Mutagen
in vitro construct
(Rao and Zipursky, 1998)
Progenitor genotype
dockUAS.cRa
(Rao and Zipursky, 1998)
Carried in construct
P{UAS-dock.W48K}
Cytology
Description

Construct: Amino acid replacement: W48K. Mutation resides within the first SH3 domain.

(Rao and Zipursky, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dock
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      dockW48K.UAS/Scer\GAL4GMR.PF is a suppressor | partially of eye photoreceptor cell & axon phenotype of Scer\GAL4GMR.PF, msnEP549

      (Ruan et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Weakly suppresses the pretarget termination phenotype of photoreceptor cell axons caused by expression of msnEP549 under the control of Scer\GAL4GMR.PF.

      (Ruan et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      dockW48K.UAS/Scer\GAL4elav.PLu rescues dock04723

      (Rao and Zipursky, 1998)
      Fails to rescue

      dockW48K.UAS/Scer\GAL4SG18.1 fails to rescue dock04723

      (Ang et al., 2003)
      Comments

      Scer\GAL4SG18.1; dockW151K.Scer\UAS (gives expression in olfactory neurons, but not in the brain) does not rescue the development of glomeruli in the antennal lobes of dock04723 homozygous flies.

      (Ang et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dockW48K.Scer\UAS
      dockW48K.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)